Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

exposure-related observations in humans: other data
Type of information:
other: General considerations
Adequacy of study:
other information
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature (review).

Data source

Referenceopen allclose all

No information
Schleyer WL and Blumberg JG (1982). Health, safety and|environmental aspects of soluble silicates. In Soluble|Silicates, Falcone JS (ed). ACS Symposium Series 194,|Chapter 4, 49-69.
No information
Select Committee on GRAS Substances, Evaluation of the Health Aspects of Certain Silicates as Food Ingredients, SCOGS-61, Federation of American Societies for Experimental Biology, NTIS Publication 301-402/AS, Springfield, Va., p.4, 1979.

Materials and methods

Type of study / information:
Type of experience: other
Principles of method if other than guideline:
General scientific considerations.

Test material

Constituent 1
Chemical structure
Reference substance name:
Silicic acid, sodium salt
EC Number:
EC Name:
Silicic acid, sodium salt
Cas Number:
Molecular formula:
Na2O x (SiO2)n with Molar Ratio (MR) (SiO2/Na2O): 1.5 – 4
sodium hydroxy(oxo)silanolate
Details on test material:
Sodium silicate, no further information on molar ratio and
concentration given.

Results and discussion

Any other information on results incl. tables

In man, the lethal oral dose of sodium silicates has been
estimated as 0.5-5 g/kg, depending on the molar ratio.

In the USA sodium silicate is considered "generally
recognized as safe (GRAS)" for indirect food uses, and as
additive to drinking water in concentrations of up to 100

Applicant's summary and conclusion