Registration Dossier
Registration Dossier
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EC number: 263-467-1 | CAS number: 62229-08-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Human lymphocytes were exposed to lead acetate alone (100 nM to 1 mM) or in combination with cadmium acetate or zinc acetate for three hours and chromosome abberations and gaps were examined.
- GLP compliance:
- not specified
- Type of assay:
- other: in vitro mammalian chromosome aberration test (migrated information)
Test material
- Reference substance name:
- Acetic acid, lead salt, basic
- EC Number:
- 257-175-3
- EC Name:
- Acetic acid, lead salt, basic
- Cas Number:
- 51404-69-4
Constituent 1
Results and discussion
Test results
- Species / strain:
- mammalian cell line, other: Human lymphocytes
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- not examined
- Remarks on result:
- other: Test system: all strains/cell types tested
Any other information on results incl. tables
Lead acetate exposure alone or in combination with cadmium and/or zinc did not increase the frequency of chromosome abberations or gaps at any concentration tested.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
- Executive summary:
Human lymphocytes were exposed to lead acetate alone (100 nM to 1 mM) or in combination with cadmium acetate or zinc acetate for three hours and chromosome abberations and gaps were examined. Lead acetate exposure alone or in combination with cadmium and/or zinc did not increase the frequency of chromosome abberations or gaps at any concentration tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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