Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 292-587-7 | CAS number: 90640-66-7
Endpoint summary
Administrative data
Description of key information
Only limited data are available for Amines, polyethylenepoly-, tetraethylenepentamine fraction. However, the registered substance is corrosive to skin and a strong base (pH >= 11.5). Therefore, no further testing is required.
Based on the harmonised classification of the main constituent of the registered substance the registered substance is also classified as Skin Sens. Cat. 1 (H317).
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There are only limited data available on skin sensitisation with Amines, polyethylenepoly-, tetraethylenepentamine fraction (CAS 90640-66-7). In order to fulfil the standard information requirements set out in Annex VII, 8.3., no further testing is required because the substance is classified as skin corrosion (Cat. 1B) and is a strong base (pH >= 11.5).
Two limited skin sensitisation studies (reliability 4) are available for the target substance Amines, polyethylenepoly-, tetraethylenepentamine fraction. Both studies on the registered substance are shortly described in publications. Both are GPMT tests (Leung, 1997; Thorgeirsson, 1978). In Leung (1997) no skin sensitisation potential was observed as only 5% of the animals showed a positive reaction after 5% intradermal induction. On the other hand, 73% guinea pigs showed positive response after 0.5% treatment with the target substance at intradermal induction (Thorgeirsson, 1978).
As both test cannot be used for classification due to limited documentation, no conclusion on classification can be drawn. However, the main constituent of the registered substance is tetraethylenpentamine (CAS 112 -57 -2) which is harmonised classified in Annex VI of Regulation (EC) No 1272/2008 as Skin Sens. Cat. 1 (H317). Therefore, the registered substance is also considered to be a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Only limited data with the registered substance on skin sensitisation are available which cannot be used for classification according to Regulation (EC) No. 1272/2008. The registered substance is skin corrosive (Cat. 1B) and a strong base (pH >= 11.5) therefore no further testing is warranted. However, the main consitutent ( tetraethylenepentamine, CAS 112 -57 -2) of the registered substance is harmonised classified in Annex VI of Regulation (EC) No 1272/2008 for skin sensitisation. Thus, the registered substance is also considered to be skin sensitising Cat. 1 (H317).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
