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EC number: 292-587-7 | CAS number: 90640-66-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial radical formation potential
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1974-1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Short summary of acute oral toxicity test, no GLP, no data on composition of the test substance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Eyes not staining with 5% fluorescein in 20 sec contact were accepted. Single installation of 0.005, 0.02, 0.10 or 0.5 mL undiluted or 0.5 mL of 40, 15, 5 or 1% dilutions were made into conjunctival sac of 5 rabbits. Read immediately unstained and after fluorescein at 24 h, with one of 10 grades assigned. Trace or no injury from 0.5 mL undiluted is grade 1.
- GLP compliance:
- no
- Remarks:
- Before GLP
Test material
- Reference substance name:
- Amines, polyethylenepoly-, tetraethylenepentamine fraction
- EC Number:
- 292-587-7
- EC Name:
- Amines, polyethylenepoly-, tetraethylenepentamine fraction
- Cas Number:
- 90640-66-7
- Molecular formula:
- C8H23N5, C10H25N5
- IUPAC Name:
- (2-aminoethyl)[2-({2-[(2-aminoethyl)amino]ethyl}amino)ethyl]amine; bis(2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- Single instillation
- Observation period (in vivo):
- No info, at least up to 24 h.
- Number of animals or in vitro replicates:
- 5
Results and discussion
In vivo
Results
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- other: moderate corneal injury
Any other information on results incl. tables
Only a description of the results was given:
- 0.02 mL per eye: moderate corneal injury with iritis in 1/5 rabbits
- 0.005 mL per eye: minor injury
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Because 0.02 mL of the undiluted test substance caused moderate corneal injury, it is expected that the amount required according the current OECD guideline (0.1 mL) will induce more severe eye injury and the test substance is therefore considered to be at least 'highly irritating'.
- Executive summary:
The test substance, Amines, polyethylenepoly-, tetraethylenepentamine fraction, was applied undiluted at a volume of 0.02 mL to the conjunctival sac of 5 rabbits. Rabbits showed moderate corneal injury, 1/5 rabbits showed iritis. A volume of 0.005 mL per eye showed minor injury. Because a volume of 0.02 mL was used, it is expected that the amount required according the current OECD guideline (0.1 mL) will induce more severe eye injury and the test substance is therefore considered to be at least 'highly irritating'. Because of lack on info when using a volume of 0.1 mL, and on reversibility, classification in OECD-GHS categories is not possible.
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