Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: exposure measurements

Data source

Reference Type:
Exposure to low molecular polyamines during road paving
Levin, J.O., Andersson, K., Hallgren, C.
Bibliographic source:
Ann occup. Hyg., Vol. 38, No 3. pp. 257 264.

Materials and methods

Type of study / information:
Measurement of TEPA in the air during road pavement.
Endpoint addressed:
other: occupational exposure
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Amines, polyethylenepoly-, tetraethylenepentamine fraction
EC Number:
EC Name:
Amines, polyethylenepoly-, tetraethylenepentamine fraction
Cas Number:
Molecular formula:
C8H23N5, C10H25N5
(2-aminoethyl)[2-({2-[(2-aminoethyl)amino]ethyl}amino)ethyl]amine; bis(2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine
Test material form:


Exposure assessment:
Details on exposure:
TEPA was found as aerosol

Results and discussion

TEPA was measured in concentrations of 0.02 to 0.05 mg/m³.

Applicant's summary and conclusion

Executive summary:

Fatty amine wetting agents are used to increase adhesion in bitumen emulsions used in road paving, but commercial fatty amine products are contaminated with low molecular polyamines and alkanol polyamines which are released from the hot bitumen during paving. Polyamines and alkanol polyamines are known to cause eye and respiratory tract irritation and skin sensitization. The exposure of road pavers to ethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, hydroxyethylethylenediamine, hydroxyethyldiethylenetriamine, monoethanolamine and diethanolamine was studied, since most of these compounds were found in the products used. Personal and static air sampling was performed during road paving. A highly sensitive measurement technique utilizing naphthylisothiocyanate-coated sorbents and filters was used. Exposure was found to be in the range <0.02-0.5 mg/m³, as total concentration of low molecular polyamines and alkanol polyamines. Since the polyamines and alkanol polyamines in question are highly irritating they may contribute to the symptoms experienced by the road pavers.