Amines, polyethylenepoly-, tetraethylenepentamine fraction

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

no data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: exposure measurements

Data source

Reference

Reference Type:

publication

Title:

Exposure to low molecular polyamines during road paving

Author:

Levin, J.O., Andersson, K., Hallgren, C.

Year:

1994

Bibliographic source:

Ann occup. Hyg., Vol. 38, No 3. pp. 257 264.

Materials and methods

Type of study / information:

Measurement of TEPA in the air during road pavement.

Endpoint addressed:

other: occupational exposure

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Amines, polyethylenepoly-, tetraethylenepentamine fraction

EC Number:

292-587-7

EC Name:

Amines, polyethylenepoly-, tetraethylenepentamine fraction

Cas Number:

90640-66-7

Molecular formula:

C8H23N5, C10H25N5

IUPAC Name:

(2-aminoethyl)[2-({2-[(2-aminoethyl)amino]ethyl}amino)ethyl]amine; bis(2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine

Test material form:

liquid

Method

Exposure assessment:

measured

Details on exposure:

TEPA was found as aerosol

Results and discussion

Results:

TEPA was measured in concentrations of 0.02 to 0.05 mg/m³.

Applicant's summary and conclusion

Executive summary:

Fatty amine wetting agents are used to increase adhesion in bitumen emulsions used in road paving, but commercial fatty amine products are contaminated with low molecular polyamines and alkanol polyamines which are released from the hot bitumen during paving. Polyamines and alkanol polyamines are known to cause eye and respiratory tract irritation and skin sensitization. The exposure of road pavers to ethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, hydroxyethylethylenediamine, hydroxyethyldiethylenetriamine, monoethanolamine and diethanolamine was studied, since most of these compounds were found in the products used. Personal and static air sampling was performed during road paving. A highly sensitive measurement technique utilizing naphthylisothiocyanate-coated sorbents and filters was used. Exposure was found to be in the range <0.02-0.5 mg/m³, as total concentration of low molecular polyamines and alkanol polyamines. Since the polyamines and alkanol polyamines in question are highly irritating they may contribute to the symptoms experienced by the road pavers.