Iron trichloride

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Publication, reasonably documented, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Potential of the rat as a model for predicting iron bioavailability for humans

Author:

Mahoney AW, Hendricks DG

Year:

1984

Bibliographic source:

Nutrition Res 4(5):913-22

Materials and methods

Principles of method if other than guideline:

Iron salt species analysed: unclear

Test material

Test material information

Constituent 1

Reference substance name:

iron sulfate

IUPAC Name:

iron sulfate

Constituent 2

Reference substance name:

Iron sulphate

EC Number:

231-753-5

EC Name:

Iron sulphate

Cas Number:

7720-78-7

IUPAC Name:

iron(2+) sulfate

Results and discussion

Main ADME results

Type:

other: bioavailability

Results:

The amount of iron absorbed by people and animals varies directly with their iron status. The average human response is 68 % that by the rats.

Any other information on results incl. tables

Justification for read-across

The surrogate material dissociates in physiological pH to the same species produced by the (iron III & II) salts after equilibration. As discussed in the category justification section, such equilibrium is quickly established. In result, iron species burden is assumed to be comparable to equimolar exposure within the iron category member salts.