Sodium p-cumenesulphonate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1968-04-23

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1968

Report date:

1968

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

6 animals were used for study instead of 10 (5 male and 5 female animals)

Principles of method if other than guideline:

None

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Sodium p-cumenesulphonate

EC Number:

239-854-6

EC Name:

Sodium p-cumenesulphonate

Cas Number:

15763-76-5

Molecular formula:

C9H12O3S.Na

IUPAC Name:

sodium 4-isopropylbenzenesulfonate

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS- Source: Not available- Age at study initiation: Not available- Weight at study initiation: 2703 grams (Abraded skin), 2730 grams (Intact skin)- Fasting period before study: Not available- Housing: Not available- Diet (e.g. ad libitum): Not available- Water (e.g. ad libitum): Not available- Acclimation period: Not availableENVIRONMENTAL CONDITIONS- Temperature (°C): Not available- Humidity (%): Not available- Air changes (per hr): Not available- Photoperiod (hrs dark / hrs light): Not availableIN-LIFE DATES: 1968-04-23

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

TEST SITE- Area of exposure: Not available- % coverage: Not available- Type of wrap if used: Not availableREMOVAL OF TEST SUBSTANCE- Washing (if done): Not available- Time after start of exposure: Not availableTEST MATERIAL- Amount(s) applied (volume or weight with unit): 2 ml/kg bw- Concentration (if solution): Not available- Constant volume or concentration used: yes- For solids, paste formed: Not availableVEHICLE- Amount(s) applied (volume or weight with unit): Not available- Concentration (if solution): Not available- Lot/batch no. (if required): Not available- Purity: Not available

Duration of exposure:

Not available

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

Total 6 animals were taken for the study. Sex was not mentioned.

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days- Frequency of observations and weighing: Not available- Necropsy of survivors performed: Not available- Other examinations performed: Clinical signs, body weight

Statistics:

None

Results and discussion

Preliminary study:

None

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

0/3 (Abraded skin), 0/3 (Intact skin)

Gross pathology:

Not available

Other findings:

- Organ weights: None- Histopathology: None- Potential target organs: None- Other observations: None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 > 2000 mg/kg bw based on test material.

Executive summary:

The acute dermal toxicity of Sodium p-cumenesulphonate was assessed following official method OECD 402, Acute dermal Toxicity. The test item elicited moderate primary irritation on the test sites.