Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to soil macroorganisms except arthropods: long-term
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification
Qualifier:
no guideline required
Principles of method if other than guideline:
The endpoints calculated are the LL50, EL50, and NOELR -
The narcosis target lipid model was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points.
GLP compliance:
no
Specific details on test material used for the study:
NA
Details on sampling:
N/A
Details on preparation and application of test substrate:
N/A
Test organisms (species):
other: Folsomia candida
Animal group:
other: Springtail
Details on test organisms:
N/A
Post exposure observation period:
N/A
Test temperature:
N/A
pH:
N/A
Moisture:
N/A
Details on test conditions:
N/A
Nominal and measured concentrations:
N/A
Key result
Duration:
28 d
Dose descriptor:
other: LL50
Effect conc.:
16.48 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Key result
Duration:
56 d
Dose descriptor:
other: NOELR
Effect conc.:
3.16 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Details on results:
N/A
Results with reference substance (positive control):
N/A
Reported statistics and error estimates:
N/A
N/A
Validity criteria fulfilled:
yes
Conclusions:
The TLM-EqP predicted effect values for ethylene were 16.48 and 3.16 mg/kg soil dw for short-term (28-day LL50) and long-term effects (56-day NOELR), respectively.
Executive summary:

The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted effect values for ethylene were 16.48 and 3.16 mg/kg soil dw for short-term (28-day LL50) and long-term effects (56 -day NOELR), respectively.

Description of key information

The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted effect values for ethylene were 16.48 and 3.16 mg/kg soil dw for short-term (28-day LL50) and long-term effects (56 -day NOELR), respectively. The ECOSAR model predicted a 14 day LC50 of 60.04mg/kg soil dw.

Key value for chemical safety assessment

Additional information

For the purpose of risk assessment, sediment PNECs for the constituent has been derived using aquatic PNECs in conjunction with the equilibrium partitioning method (EqP).