Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Due to its high adsorption and low toxicity to aquatic organisms, ATMP-N-oxide was assigned to soil hazard category 3. The aquatic studies indicate that vertebrate and invertebrate toxicity is relatively comparable, while algal studies are complicated by complexation effects. The PNECscreen was conducted, based on the equilibrium partitioning method (PEC * 10 / PNECscreen) and following ECHA’s test proposal evaluation, a long-term study to soil invertebrates (OECD 222) has been commissioned, to be conducted with ATMP sodium salt (a neutralised form of ATMP) and read across to the ATMP-N-oxide-5K registration substance (with appropriate mass correction).

The study report is not expected to be available in time for the ECHA decision deadline of 15th December 2020, therefore an update will be submitted by June 2021 and results from this study will be used in due course to derive a new PNECsoil value for the chemical safety assessment. Please refer to IUCLID Section 6.3.1 and Section 7.2.1 of the CSR for further information.

Additional information

ATMP-N-oxide and their salts are highly adsorbing to soil and soil mineral substrates. The nature of the adsorption is believed to be primarily due to interaction with inorganic substrate or generalised surface interactions. High adsorption is consistent with similar behaviour seen for the analogues ATMP, DTPMP and HEDP, and other common complexing agents such as EDTA. By reference to findings with other similar substances, the binding occurs very rapidly and is effectively irreversible. For environmental fate purposes in exposure assessment this is assessed as a removal process.


Please refer to IUCLID Section 13 for further information on the read-across from the ATMP category to the ATMP-N-oxide category.