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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
test procedure simillar to OECD 105
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
modified taking into account the very low solubility of the test substance
Principles of method if other than guideline:
Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
Type of method:
flask method
Water solubility:
4.6 µg/L
Temp.:
22 °C
pH:
ca. 7
Remarks on result:
other: mean of 3 measurements

The solubility of the sample C.I. Pigment Red 181 in water at ambient temperature, determined under the conditions as mentioned above, is 4.6 µg/L (mean, n = 3, sigma = 0.5).

Table 1: Individual results

   Absorption (d = 10 cm)  µg/L
 a1 0.00148  4.0
 a2 0.00181  4.8
 a3 0.00185  4.9
Conclusions:
the test substance is practically insoluble in water (< 0.1 mg/L)
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer); method similar to Annex V, A.8, 1.6.1, Directive 67/548/EEC
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
other: ETAD Analytical Expert Group
Version / remarks:
methold for substances with very low solubility in both, water and n-octanol
Principles of method if other than guideline:
Based on the determined solubilities in water and in n-octanol the partition coefficient was estimated (chapter 1.6.1, A.8). Instead of saturated solvent
systems pure solvents were used.
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
2.06
Temp.:
22 °C
pH:
ca. 7
Type:
Pow
Partition coefficient:
115.22
Temp.:
22 °C
pH:
ca. 7

Solubility of Pigment Red 181 in n-octanol: 530 µg/l

Water solubility of Pigment Red 181 : 4.6 µg/l

Pow PR 181 = 115.22

log Pow PR 181 = 2.06

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Analytical Expert Group ETAD
Principles of method if other than guideline:
Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Test material

Constituent 1
Chemical structure
Reference substance name:
6-chloro-2-(6-chloro-4-methyl-3-oxobenzo[b]thien-2(3H)-ylidene)-4-methylbenzo[b]thiophene-3(2H)-one
EC Number:
219-163-6
EC Name:
6-chloro-2-(6-chloro-4-methyl-3-oxobenzo[b]thien-2(3H)-ylidene)-4-methylbenzo[b]thiophene-3(2H)-one
Cas Number:
2379-74-0
Molecular formula:
C18H10Cl2O2S2
IUPAC Name:
6-chloro-2-[(2E)-6-chloro-4-methyl-3-oxo-2,3-dihydro-1-benzothiophen-2-ylidene]-4-methyl-2,3-dihydro-1-benzothiophen-3-one
Test material form:
solid: nanoform

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
n-octanol
Solubility:
0.53 mg/L
Temp.:
22 °C
Remarks on result:
other: mean of 3 measurements
Test substance stable:
yes

Any other information on results incl. tables

The solubility of the sample C.I. Pigment Red 181 in n-octanol at ambient temperature, determined under the conditions as mentioned above, is 0.53 mg/L (mean, n = 3,sigma= 0.01).

Table 1: Individual results

   Absorption (d = 10 cm)  mg/L
 a1 0.2244  0.53
 a2 0.2245  0.53
 a3 0.2278

0.54

Applicant's summary and conclusion