Guanidinium nitrate

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

peer-reviewed

Qualifier:

equivalent or similar to guideline

Guideline:

other: not reported

Principles of method if other than guideline:

test guiceline not specified in peer revied handbook

GLP compliance:

no

Type of method:

other: not specified

Water solubility:

44.3 g/L

Temp.:

0 °C

pH:

ca. 7

Water solubility:

10 vol%

Temp.:

15 °C

pH:

ca. 7

Key result

Water solubility:

256 g/L

Temp.:

20 °C

pH:

ca. 7

Water solubility:

140.7 g/L

Temp.:

25 °C

pH:

ca. 7

Water solubility:

292 g/L

Temp.:

50 °C

pH:

ca. 7

Water solubility:

423 g/L

Temp.:

75 °C

pH:

ca. 7

In the peer-reviewed document the water solubility of guanidinium nitrate is reported to be in the range between 44 and 423 g/L (in the temperature range between 0 and 75 °C) and 256 g/L at 20 °C.

Water solubility, g/L	Temperature, °C	Refs.
44,3	0	1
10%	15	2
256	20	3
140,7	25	4
292	50	5
423	75	6

Ref. 1	1468122; Journal; Blair; Braham; IECHAD; Industrial and Engineering Chemistry; 16; 1924; 850; ISSN: 0019-7866; CHZEA6; Chem. Zentralbl.; German; 95; II; 1924; 2140
Ref. 2	1475923; Book Review / Secondary Ref.; Davis; Org.Synth.Coll.Vol. I<1941>303
Ref. 3	1477265; Journal; Smith; Sabetta; Steinbach; IECHAD; Industrial and Engineering Chemistry; 23; 1931; 1127,1128; ISSN: 0019-7866
Ref. 4	1468122; Journal; Blair; Braham; IECHAD; Industrial and Engineering Chemistry; 16; 1924; 850; ISSN: 0019-7866; CHZEA6; Chem. Zentralbl.; German; 95; II; 1924; 2140
Ref. 5	1468122; Journal; Blair; Braham; IECHAD; Industrial and Engineering Chemistry; 16; 1924; 850; ISSN: 0019-7866; CHZEA6; Chem. Zentralbl.; German; 95; II; 1924; 2140
Ref. 6	1477265; Journal; Smith; Sabetta; Steinbach; IECHAD; Industrial and Engineering Chemistry; 23; 1931; 1127,1128; ISSN: 0019-7866

Conclusions:

Interpretation of results: very soluble (> 10000 mg/L)
In the peer-reviewed document the water solubility of guanidinium nitrate is reported to be in the range between 44 and 423g/L (in the temperature range between 0 and 75°C) and 256 g/L at 20°C.

Executive summary:

In the peer-reviewed document the water solubility of guanidinium nitrate is reported to be in the range between 44 and 423g/L (in the temperature range between 0 and 75°C) and 256 g/L at 20°C.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

peer-reviewed

Justification for type of information:

Supporting information for read-across, structural analogue approach.

Principles of method if other than guideline:

reviewed handbook data (method not reported)

GLP compliance:

not specified

Key result

Water solubility:

2 150 g/L

Temp.:

20 °C

Remarks on result:

other: stated as 215 g/100g

Key result

Water solubility:

3 200 g/L

Temp.:

55 °C

Remarks on result:

other: stated as 320 g/100g

Conclusions:

Interpretation of results: very soluble (> 10000 mg/L)
The solubility of guanidinium chloride in water is reported to be 2150 g/l at 20 °C.

Executive summary:

The solubility of guanidinium chloride in water is reported to be 2150 g/l at 20 °C.

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

GLP compliance:

no

Key result

Water solubility:

ca. 125 g/L

Temp.:

20 °C

Conclusions:

Interpretation of results: very soluble (> 10000 mg/L)
In the peer-reviewed document the water solubility of Guanidine nitrate is reported to be ca. 125 g/L (derived from a Graph) at 20°C.

Executive summary:

In the peer-reviewed document the water solubility of Guanidine nitrate is reported to be ca. 125 g/L (derived from a Graph) at 20°C.

Description of key information

The water solubility of Guanidine Nitrate is 256g/L at 20°C.

Key value for chemical safety assessment

Water solubility:

256 g/L

at the temperature of:

20 °C

Additional information

The water solubility of guanidinium nitrate is reported to be in the range between 44 and 423g/L (in the temperature range between 0 and 75°C) and 256 g/L at 20°C (Beilstein handbook, 2009).

In contrast, a smaller value about 125 g/L at 20°C was reported by the American Cynamid Company (1937). This could be explained because the value was derived from a graph. To enable functionalities within Chesar v.1.2, water solubility (here being out of range with a value of 2.56E+05 mg/L) was set to the maximum value of the range advised by the implemented EUSES program, i.e. to <1E+05 mg/L. Additional supporting data from the read-across substance guanidine chloride were included to demonstrate the similar physico-chemical profile of both substances, used to substantiate the justification for read-across, outlined in chapter 13 of technical dossier.