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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-08-29
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
GLP compliance:
not specified
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
133.91 µm
Remarks on result:
not determinable
Key result
Percentile:
D10
Mean:
62.72 µm
Remarks on result:
other: SD not determined
Key result
Percentile:
D25
Mean:
117.8 µm
Remarks on result:
other: SD not determined
Key result
Percentile:
D50
Mean:
242.13 µm
Remarks on result:
other: SD not determined
Key result
Percentile:
D75
Mean:
415.73 µm
Remarks on result:
other: SD not determined
Key result
Percentile:
D90
Mean:
591.98 µm
Remarks on result:
other: SD not determined
Key result
Percentile:
other: D100
Mean:
1 030 µm
Remarks on result:
other: SD not determined
Conclusions:
26 % of the particles have a diameter < 125 µm, 13 % < 71µm.
As the substance is highly water soluble (>100g/l), particles inhaled are quickly solved.
Executive summary:

26 % of the particles have a diameter < 125 µm, 13 % < 71µm.

As the substance is highly water soluble (>100g/l), particles inhaled are quickly solved.

Description of key information

26 % of the particles have a diameter < 125 µm, 13 % < 71µm.

Additional information

According to company data of AlzChem (2018) 26 % of the particles of Guanidine Nitrate have a diameter < 125 µm, 13 % < 71µm. As the substance is highly water soluble (>100g/l), particles inhaled are quickly solved.