Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
cytotoxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards. Only abstract available.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: XTT assay
Principles of method if other than guideline:
XTT assay with human gingival fibroblasts (HGF).
GLP compliance:
not specified
Type of method:
in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
EC Number:
254-588-0
EC Name:
2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
Cas Number:
39670-09-2
Molecular formula:
C12H22O5
IUPAC Name:
2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
Details on test material:
- Substance: Ethyltriglycol methacrylate (ETMA)
- Purity: not specified, but commercial grade assumed

Results and discussion

Details on results:
The Cytotoxic effect of Ethyltriglycol methacrylate on human gingival fibroblasts (HGF) was EC50 (half-maximum effect concentration): 12.000 mmol/L ((1.100 standard deviation) according to XTT assay.

Applicant's summary and conclusion

Conclusions:
The Cytotoxic effect of Ethyltriglycol methacrylate on human gingival fibroblasts (HGF) was EC50 (half-maximum effect concentration): 12.000 mmol/L ((1.100 standard deviation) according to XTT-based cell viability assay.
Executive summary:

The Cytotoxic effect of Ethyltriglycol methacrylate on human gingival fibroblasts (HGF) was assessed XTT-based cell viability assay. Each experiment was performed at least four times. The EC50 for Ethyltriglycol methacrylate was determined to be 12.000 mmol/L ((1.100 standard deviation).