Registration Dossier
Registration Dossier
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EC number: 224-699-9 | CAS number: 4454-16-4
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.23 mg/m³
DNEL related information
- Dose descriptor starting point:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 520 mg/m³
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.23 mg/m³
DNEL related information
- Dose descriptor:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8 mg/m³
DNEL related information
- Dose descriptor starting point:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.37 mg/kg bw/day
DNEL related information
- Dose descriptor starting point:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.002 mg/cm²
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
In order to evaluate toxicological properties of the substance nickel bis(2-ethylhexanoate), information on the assessment entities nickel cation and 2 -ethylhexanoate anion were considered. For a documentation and justification of that approach, please refer to the separate document attached to section 13, namely Read Across Assessment Report for nickel bis(2-ethylhexanoate).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0 mg/m³
DNEL related information
- Dose descriptor starting point:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 44 mg/m³
DNEL related information
- Dose descriptor starting point:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0 mg/m³
DNEL related information
- Dose descriptor:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.5 mg/m³
DNEL related information
- Dose descriptor starting point:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.19 mg/kg bw/day
DNEL related information
- Dose descriptor starting point:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.002 mg/cm²
DNEL related information
- Dose descriptor:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.043 mg/kg bw/day
DNEL related information
- Dose descriptor starting point:
- other: Derivation of the DNELs for nickel bis(2-ethylhexanoate) is based on the point of departure for the most sensitive endpoint for each individual constituent (nickel and 2-ethylhexanoic acid).
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
In order to evaluate toxicological properties of the substance nickel bis(2-ethylhexanoate), information on the assessment entities nickel cation and 2 -ethylhexanoate anion were considered. For a documentation and justification of that approach, please refer to the separate document attached to section 13, namely Read Across Assessment Report for nickel bis(2-ethylhexanoate).
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