Registration Dossier
Registration Dossier
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EC number: 225-716-2 | CAS number: 5026-74-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The study performed to determine the toxicity of the substance to aquatic algae and cyanobacteria was a static study on Pseudokirchneriella subcapitata with 72 hour exposure according to OECD 201 and the Commission Regulation (EC) no 440/2008, C3. The study was testing the substance at the nominal exposed concentrations of 3.2, 3.3, 5.5, 33 and 34 mg/l.
Key value for chemical safety assessment
Additional information
The study was testing the toxicity to aquatic algae on Pseudokirchneriella subcapitata under GLP conditions and according to OECD Guideline 201 " Fresh Water Algal Growth Inhibition Test" and was also meeting the test methods and validity criteria of the ISO International Standard 8692, 2004, the Commission Regulation (EC) No 440/2008 Part C.3, 2008 and the OECD guidance document number 23, 2000.
Under the conditions of the present study with Pseudokirchneriella subcapitata, p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline reduced growth rate of this fresh water algae species significantly at an average exposure concentration of 26 mg/l. The EC50 for growth rate reduction (ERC50: 0-72h) was 13 mg/l with a 95% confidence interval ranging from 8.3 to 19 mg/l. The EC50 for yield inhibition (EYC50: 0-72h) was 7.0 mg/l with a 95% confidence interval ranging from 5.3 to 9.3 mg/l. The NOEC for growth rate reduction was 4.2 mg/l, while the NOEC for yield inhibition could only be estimated to be < 2.5 mg/l.
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