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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

No effects were measured at the concentration representing the limit of water solubility

Key value for chemical safety assessment

Additional information

There are no studies available on the short-term toxicity of Fatty acids, tall-oil, Bu esters (CAS 67762 -63 -4) to fish. The assessment was therefore based on studies conducted with the structurally most similar category members, for which data is available, Fatty acids, C16-C18 and C18 unsatd., branched and linear, Bu esters (CAS 163961-32-8), Isopropyl oleate (CAS 112-11-8) and Fatty acids, C8 -16, 2 -ethylhexyl esters (CAS 135800 -37 -2), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.

In the selected key study, the acute toxicity of Fatty acids, C16-C18 and C18 unsatd., branched and linear, Bu esters (CAS 163961-32-8) to rainbow trout (Oncorhynchus mykiss) was tested under semi-static conditions according to OECD 203 and GLP as limit test (Wetton and McKenzie 2004). The tested concentration of 0.2 mg/L (nominal) was applied in a solvent-spike method (with acetone). The analysis of the bioavailable concentration resulted in a value of 0.045 mg/L. Since no toxic or sublethal effects were observed within the incubation period of 96 hours at the limit of water solubility an EL50(96h) > 0.045 mg/L was stated.

A supporting study with Isopropyl oleate (CAS 112-11-8) supports the absence of toxic effects up to the limit of water solubility. Cyprinus carpio was tested according to OECD 203 under static conditions using acetone as solvent (Bogers 1997). No mortalities were observerd in this limit test (LC50 > 100 mg/L).

In another read-across from Fatty acids, C8 -16, 2 -ethylhexyl esters (CAS 135800 -37 -2), the marine species Scopthalmus maximus was tested with a WAF, resulting in a LL50(96h) value > 5600 mg/L (nominal)(Hudson 2002).

Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on fish are expected up to the limit of water solubility for Fatty acids, tall-oil, Bu esters (CAS 67762 -63 -4).