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EC number: 231-714-2 | CAS number: 7697-37-2
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- NA
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only an abstract is available.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of breathing nitrate aerosols in high concentration for 10 minutes on pulmonary function of normal and asthmatic adults, and preliminary results in normals exposed to nitric acid fumes.
- Author:
- Sackner MA and Ford D
- Year:
- 1 981
- Bibliographic source:
- Am. Rev. Resp. Dis. 123: 151.
Materials and methods
- Type of study / information:
- Preliminary results of adults exposed to nitric acid fumes.
- Endpoint addressed:
- acute toxicity: inhalation
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- N/A
- GLP compliance:
- no
Test material
- Reference substance name:
- Nitric acid
- EC Number:
- 231-714-2
- EC Name:
- Nitric acid
- Cas Number:
- 7697-37-2
- Molecular formula:
- HNO3
- IUPAC Name:
- nitric acid
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): nitric acid
- Molecular formula (if other than submission substance): N/A
- Molecular weight (if other than submission substance): N/A
- Smiles notation (if other than submission substance): N/A
- InChl (if other than submission substance): N/A
- Structural formula attached as image file (if other than submission substance): N/A
- Substance type: N/A
- Physical state: N/A
- Analytical purity: N/A
- Impurities (identity and concentrations): N/A
- Composition of test material, percentage of components: N/A
- Isomers composition: N/A
- Purity test date: N/A
- Lot/batch No.: N/A
- Expiration date of the lot/batch: N/A
- Radiochemical purity (if radiolabelling): N/A
- Specific activity (if radiolabelling): N/A
- Locations of the label (if radiolabelling): N/A
- Expiration date of radiochemical substance (if radiolabelling): N/A
- Stability under test conditions: N/A
- Storage condition of test material: N/A
- Other: N/A
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Five normal adults were exposed to nitric acid fumes in a concentration of 1.6 ppm in air for 10 minutes.
- Exposure assessment:
- not specified
- Details on exposure:
- N/A
Results and discussion
- Results:
- The vital capacity,total respiratory resistance, and FEV1.0 were not affected over a 1 hour follow up period.
Any other information on results incl. tables
N/A
Applicant's summary and conclusion
- Conclusions:
- Nitric acid fumes (1.6 ppm) for 10 minutes did not produce acute bronchoconstriction in normal adults.
- Executive summary:
N/A
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