Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Currently viewing:

Administrative data

exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only an abstract is available.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference Type:
Effects of breathing nitrate aerosols in high concentration for 10 minutes on pulmonary function of normal and asthmatic adults, and preliminary results in normals exposed to nitric acid fumes.
Sackner MA and Ford D
Bibliographic source:
Am. Rev. Resp. Dis. 123: 151.

Materials and methods

Type of study / information:
Preliminary results of adults exposed to nitric acid fumes.
Endpoint addressed:
acute toxicity: inhalation
Test guideline
no guideline followed
Principles of method if other than guideline:
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Nitric acid
EC Number:
EC Name:
Nitric acid
Cas Number:
Molecular formula:
nitric acid
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): nitric acid
- Molecular formula (if other than submission substance): N/A
- Molecular weight (if other than submission substance): N/A
- Smiles notation (if other than submission substance): N/A
- InChl (if other than submission substance): N/A
- Structural formula attached as image file (if other than submission substance): N/A
- Substance type: N/A
- Physical state: N/A
- Analytical purity: N/A
- Impurities (identity and concentrations): N/A
- Composition of test material, percentage of components: N/A
- Isomers composition: N/A
- Purity test date: N/A
- Lot/batch No.: N/A
- Expiration date of the lot/batch: N/A
- Radiochemical purity (if radiolabelling): N/A
- Specific activity (if radiolabelling): N/A
- Locations of the label (if radiolabelling): N/A
- Expiration date of radiochemical substance (if radiolabelling): N/A
- Stability under test conditions: N/A
- Storage condition of test material: N/A
- Other: N/A


Ethical approval:
not specified
Details on study design:
Five normal adults were exposed to nitric acid fumes in a concentration of 1.6 ppm in air for 10 minutes.
Exposure assessment:
not specified
Details on exposure:

Results and discussion

The vital capacity,total respiratory resistance, and FEV1.0 were not affected over a 1 hour follow up period.

Any other information on results incl. tables


Applicant's summary and conclusion

Nitric acid fumes (1.6 ppm) for 10 minutes did not produce acute bronchoconstriction in normal adults.
Executive summary: