Amines, polyethylenepoly-

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Study period:

no data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Short summary of test results

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

no data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Qualifier:

no guideline followed

Principles of method if other than guideline:

Acute percutaneous absorption test

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

yes

Species:

rabbit

Strain:

New Zealand White

Sex:

female

Type of coverage:

not specified

Vehicle:

not specified

Duration of exposure:

no data

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

2 females

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

none

Clinical signs:

other: After treatment, the rabbits appeared listless and had slight tremors. However, both recovered, appeared healthy, and gained weight during the 2-week observation period.

Interpretation of results:

other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008

Conclusions:

The LD50 via the dermal route appeared to be in excess of 2000 mg/kg bw.

Executive summary:

A sample of polyethylenepolyamine neutralized, reference 30339-23-485, was submitted to the Acute Toxicology Laboratory of Health & Environmental Sciences-Texas for evaluation of acute percutaneous absorption and eye irritation potential. The test material, a reaction product of E-100, EDC,5 EPI/DETAand NaOH,also known as PAPA+1 (neutralized), was submitted by Chlor-Nitrogen Research.

 

Acute percutaneous absorption and eye Irritation tests were conducted using female Zealand albino rabbits (Ray Nichols Rabbitry).

  

The acute percutaneous absorption potential is low; range-finding tests indicate the LD50 is>2000 mg/kg. Two female rabbits were treated with 2000 mg/kg of the test material in an acute percutaneous absorption test. After treatment, the rabbits appeared restless and had slight tremors. However, both recovered, appeared healthy and gained weight during the 2-week observation period.

 

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Amines, polyethylenepoly-

EC Number:

268-626-9

EC Name:

Amines, polyethylenepoly-

Cas Number:

68131-73-7

Molecular formula:

Not applicable (i.e., complex UVCB substance)

IUPAC Name:

Amines, polyethylenepoly-

Details on test material:

Polyethylenepolyamine, neutralized
Reference number 30339-23-485
a reaction product of E-100, EDC, 5EPI/DETA, and NaOH, also known as PAPA+1 (neutralized)

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Test system

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

no data

Duration of treatment / exposure:

eyes were washed and unwashed

Observation period (in vivo):

15 days

Number of animals or in vitro replicates:

no data

Results and discussion

In vivo

Irritant / corrosive response data:

Instillation of the test material into the eyes of a rabbit resulted in severe pain, moderate conjunctival irritation, and moderate, transient clouding of the cornea. No irritationwasobserved in either the washed or unwashed eye 15 days post-instillation.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

Instillation of the test material into the eyes of a rabbit resulted in severe pain, moderate conjunctival irritation, and moderate, transient clouding of the cornea.

Executive summary:

A sample of polyethylenepolyamine neutralized, reference 30339-23-485, was submitted to the Acute Toxicology Laboratory of Health & Environmental Sciences-Texas for evaluation of acute percutaneous absorption and eye irritation potential. The test material, a reaction product of E-100, EDC,5 EPI/DETAand NaOH,also known as PAPA+1 (neutralized), was submitted by Chlor-Nitrogen Research.

 

Acute percutaneous absorption and eye Irritation tests were conducted using female Zealand albino rabbits (Ray Nichols Rabbitry).

  

Instillation of the test material into the eyes of a rabbit resulted in severe pain, moderate conjunctival irritation, and moderate, transient clouding of the cornea. No irritationwasobserved in either the washed or unwashed eye 15 days post-instillation. Chemical workers goggles should be worn whenever the likelihood of eye contact exists. If contact should occur, flush eyes with, plenty of flowing water.