Registration Dossier
Registration Dossier
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EC number: 268-626-9 | CAS number: 68131-73-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute percutaneous absorption test
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Amines, polyethylenepoly-
- EC Number:
- 268-626-9
- EC Name:
- Amines, polyethylenepoly-
- Cas Number:
- 68131-73-7
- Molecular formula:
- Not applicable (i.e., complex UVCB substance)
- IUPAC Name:
- Amines, polyethylenepoly-
- Details on test material:
- Polyethylenepolyamine, neutralized
Reference number 30339-23-485
a reaction product of E-100, EDC, 5EPI/DETA, and NaOH, also known as PAPA+1 (neutralized)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2 females
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: After treatment, the rabbits appeared listless and had slight tremors. However, both recovered, appeared healthy, and gained weight during the 2-week observation period.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008
- Conclusions:
- The LD50 via the dermal route appeared to be in excess of 2000 mg/kg bw.
- Executive summary:
A sample of polyethylenepolyamine neutralized, reference 30339-23-485, was submitted to the Acute Toxicology Laboratory of Health & Environmental Sciences-Texas for evaluation of acute percutaneous absorption and eye irritation potential. The test material, a reaction product of E-100, EDC,5 EPI/DETAand NaOH,also known as PAPA+1 (neutralized), was submitted by Chlor-Nitrogen Research.
Acute percutaneous absorption and eye Irritation tests were conducted using female Zealand albino rabbits (Ray Nichols Rabbitry).
The acute percutaneous absorption potential is low; range-finding tests indicate the LD50 is>2000 mg/kg. Two female rabbits were treated with 2000 mg/kg of the test material in an acute percutaneous absorption test. After treatment, the rabbits appeared restless and had slight tremors. However, both recovered, appeared healthy and gained weight during the 2-week observation period.
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