Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 268-626-9 | CAS number: 68131-73-7
Endpoint summary
Administrative data
Description of key information
Additional information
Experimental data on the toxicity of Amines, polyethylenepoly (PEPA; CAS 68131-73-7) to terrestrial organisms are available for earthworms (soil macroorganisms). Earthworms are responsible for the breakdown and incorporation of organic matter into the soil and thus will be mainly exposed via the uptake of soil material and via contact with soil pore water. The main exposure route of the animals is dependent on the bioavailability and thus the substance properties. The test substance is characterized by a high water solubility (WS >50 g/L), a low vapour pressure (7.65E-4 Pa) and a log Koc >3.5. Thus the substance is expected to be present in soil pore water and adsorb to soil and suspended matter. Furthermore the substance is not readily biodegradable. Thus, in accordance with section R.7.11.5.3. of Chapter R.7c of the ECHA Guidance on information requirements and chemical safety assessment (ECHA, 2017) long-term tests were conducted in order to assess the toxicity of the substance to terrestrial organisms. The toxicity to earthworms was tested according to OECD guideline 222 with Eisenia fetida as test species. During an exposure period of 56 days (in total) the mortality of adult earthworms as well as the reproduction rate were recorded. An effect of the substance on the reproduction rate was not determined. The reported NOEC is 1000 mg/kg soil dw.
Additionally data from a short summary on the toxicity to birds of the read across substance N,N'-bis(2-aminoethyl)ethane-1,2-diamine (CAS 112-24-3) are available. Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol. The LD50 was estimated based on the food consumption measured over a period of 18 hours. A LD50 (18 h) of 100 - 133 mg/kg was calculated.
The available data is deemed sufficient to assess the terrestrial toxicity of the test substance. Further tests on soil organisms are therefore not conducted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
