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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given. There are reporting deficiencies, e.g. housing conditions and purity were not stated. In addition only 5 test animals were used.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
; reporting deficiencies, e.g. housing conditions and purity not given, only 5 test animals used
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Diisopropyl adipate
EC Number:
230-072-0
EC Name:
Diisopropyl adipate
Cas Number:
6938-94-9
Molecular formula:
C12H22O4
IUPAC Name:
1,6-bis(propan-2-yl) hexanedioate
Details on test material:
- Name of test material: adipate d'isopropyle
- Physical state: liquid
- Analytical purity: no data

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Animal strain as given in the report: NMRI EOPS
- Weight at study initiation: 18 to 20 g
- Fasting period before study: 4 h

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED:
In the report a dose volume of 40 mL/kg bw is stated. This is considered to be a calculation error for the following reasons:
The physical state of the test substance is liquid and therefore it was administered unchanged in the limit test.
The density of the test substance at 20 °C is 0.97 g/mL corresponding to an applied dose volume of approx. 5 mL/kg bw.


Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5 males
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: animals were observed daily and individual body weights were determined weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occurred during the study period.
Clinical signs:
other: Lethargy, half closed eyes and forced breathing were evident up to 1 h after dosing.
Gross pathology:
Necropsy revealed no substance-related findings.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
CLP: not classified
DSD: not classified