Registration Dossier
Registration Dossier
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EC number: 200-849-9 | CAS number: 75-21-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Genotoxic effects of ethylene oxide and propylene oxide: a comparative study.
- Author:
- Agurell, E., Cederberg, H., Ehrenberg, L., Lindal-Kiessling, K. Rannug, U., Törnqvist, M.
- Year:
- 1 991
- Bibliographic source:
- Mutation Research 250, 229 - 237
Materials and methods
- Principles of method if other than guideline:
- according to Maron, D.M. and Ames, B.N.: Mut. Res. 113, 173-215
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Ethylene oxide
- EC Number:
- 200-849-9
- EC Name:
- Ethylene oxide
- Cas Number:
- 75-21-8
- Molecular formula:
- C2H4O
- IUPAC Name:
- oxirane
Constituent 1
Method
- Target gene:
- S. typhimurium strains
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535
- Species / strain / cell type:
- S. typhimurium TA 100
- Metabolic activation:
- without
- Metabolic activation system:
- no data
- Test concentrations with justification for top dose:
- 0 - 12 mMh
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- EO gave a dose-dependent increase in the number of revertants on both tester strains.
Applicant's summary and conclusion
- Conclusions:
- In conclusions, under the conditions chosen the test substance induced mutations in the salmonella typhimurium strains TA 100 and TA 1535 and thus, is considered to be mutagenic.
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