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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-aminoethanol
EC Number:
205-483-3
EC Name:
2-aminoethanol
Cas Number:
141-43-5
Molecular formula:
C2H7NO
IUPAC Name:
2-aminoethanol
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
1, 5, 15 min, 20 hrs
Observation period:
8 days
Number of animals:
2
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5 cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 1, 5 and 15 min, respectively

SCORING SYSTEM: The original scoring system was converted into Draize scores

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Remarks:
1 min exposure
Basis:
mean
Time point:
24/48/72 h
Score:
1.5
Max. score:
4
Reversibility:
fully reversible within: 8 days
Irritation parameter:
edema score
Remarks:
1 min exposure
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Remarks:
5 min exposure
Basis:
mean
Time point:
24/48/72 h
Score:
1.5
Max. score:
4
Reversibility:
fully reversible within: 8 days
Irritation parameter:
edema score
Remarks:
5 min exposure
Basis:
mean
Time point:
24/48/72 h
Score:
0.16
Max. score:
4
Reversibility:
fully reversible within: 48 h
Irritation parameter:
erythema score
Remarks:
15 min exposure
Basis:
mean
Time point:
24/48/72 h
Score:
1.83
Max. score:
4
Reversibility:
fully reversible within: 8 days
Irritation parameter:
edema score
Remarks:
15 min exposure
Basis:
mean
Time point:
24/48/72 h
Score:
0.66
Max. score:
4
Reversibility:
fully reversible within: 8 days
Irritation parameter:
erythema score
Remarks:
20 hr exposure
Basis:
mean
Time point:
24/48/72 h
Score:
3
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
edema score
Remarks:
20 hr exposure
Basis:
mean
Time point:
24/48/72 h
Score:
1.33
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Other effects:
bleedings and necrosis of the skin

Any other information on results incl. tables

 

Readings

Animal

Exposure period: 1 min

Erythema

Edema

Additional findings

1 min

1

2

0

spotted appearance

2

0

0

 

24 h

1

2

0

spotted appearance

2

1

0

 

48 h

1

2

0

spotted appearance

2

1

0

 

72 h

1

2

0

spotted appearance

2

0

0

 

8 d

1

0

0

slight desquamation

2

0

0

 

Mean 24, 48, 72 h

1

2

0

 

2

0.66

0

 

Mean 24, 48, 72 h

1-2

1.33

0

 

 

Readings

Animal

Exposure period: 5 min

Erythema

Edema

Additional findings

5 min

1

2

0

pea-sized spotted erythema, bleedings

2

3

0

bleedings

24 h

1

2

0

spotted appearance

2

2

2

grey-brown appearance

48 h

1

2

0

spotted appearance

2

0

0

leather-like necrosis

72 h

1

2

0

spotted appearance

2

0

0

brown-red leather-like necrosis, partly anaemic

8 d

1

0

0

pea-sized crusts, desquamation

2

0

0

brown-red leather-like necrosis, partly anaemic

Mean 24, 48, 72 h

1

2

0

 

2

1

0.33

 

Mean 24, 48, 72 h

1-2

1.5

0.16

 

 

Readings

Animal

Exposure period: 15 min

Erythema

Edema

Additional findings

15 min

1

2

0

bleedings

2

3

0

bleedings

24 h

1

2

2

pea-sized brown erythema

2

2

0

grey-brown spotted appearance, bleedings

48 h

1

2

2

pea-sized brown erythema

2

0

0

leather-like anaemic necrosis exceeding area of exposure

72 h

1

3

0

pea-sized crusts, spotted appearance

2

0

0

brown-red leather-like necrosis, partly anaemic

8 d

1

0

0

pea-sized crusts, desquamation

2

0

0

brown-red leather-like necrosis, partly anaemic

Mean 24, 48, 72 h

1

2

1.33

 

2

1.66

0

 

Mean 24, 48, 72 h

1-2

1.83

0.66

 

 

Readings

Animal

Exposure period: 20 hours

Erythema

Edema

Additional findings

24 h

1

3

2

grey-brown, exceeding area of exposure

2

3

2

grey-brown anaemic necrosis,

48 h

1

3

2

grey-brown, exceeding area of exposure

2

3

0

black brown hard necrosis

72 h

1

3

2

black-brown slideable necrosis

2

3

0

black brown hard necrosis

8 d

1

3

2

black-brown slideable necrosis

2

3

0

black brown hard necrosis

Mean 24, 48, 72 h

1

3

2

 

2

3

0.66

 

Mean 24, 48, 72 h

1-2

3

1.33

 

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria