Registration Dossier
Registration Dossier
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EC number: 211-463-5 | CAS number: 646-06-0
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted by Industrial Bio-Test Laboratories in 1977. This lab was investigated by the US EPA in 1978 and found to deliver study reports with questionable results. Mammalian toxicology studies conducted during the 1960's and until 1978 by Industrial Bio-Test Laboratories should therefore be used with great care. The OECD HPV programme has produced guidance on how to treat these studies. A study by Industrial Bio-Test Laboratories which has not been audited by EPA/FDA nor by Industry, should be rejected unless findings are consistent with a study conducted at a later date, in which case the study by Industrial Bio-Test Laboratories represents weak evidence. The present study was not audited, and no comparable study performed by another lab at a later date is available. Therefore the study is rejected as unreliable (reliability 3).
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test material
- Reference substance name:
- 1,3-dioxolane
- EC Number:
- 211-463-5
- EC Name:
- 1,3-dioxolane
- Cas Number:
- 646-06-0
- Molecular formula:
- C3H6O2
- IUPAC Name:
- 1,3-dioxolane
Constituent 1
Administration / exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
