Registration Dossier
Registration Dossier
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EC number: 211-463-5 | CAS number: 646-06-0
Endpoint summary
Administrative data
Description of key information
For the oral route, 2 reliable acute toxicity studies in rats were identified. These studies indicate low acute oral toxicity for 1,3-Dioxolane, with a LD50 exceeding 2000 mg/kg bw.
For the inhalation route, one reliable acute toxicity study in rats was identified, indicating low acute inhalatory toxicity for 1,3-Dioxolane, with a LC50 of 68.4 mg/L (0.0684 mg/m3).
There are no data on acute dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 68 400 mg/m³ air
Additional information
For 1,3-Dioxolane, the acute oral toxicty in rats was >2000 mg/kg bw and needs not to be classified for acute oral toxicity.
The acute inhalation toxicity for 1,3-Dioxolane in rats was 68.4 mg/L, and based on these results, 1,3-Dioxolane needs not to be classified for acute inhalation toxicity.
Based on the observed lack of acute toxicity by the oral and inhalatory route, no acute dermal toxicty is to be expected. Therefore, 1,3-Dioxolane needs not to be classified for acute dermal toxicity.
Justification for classification or non-classification
According to CLP, 1,3-Dioxolane needs no classification for acute oral, dermal and inhalation toxicity.
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