2-Butanone, peroxide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

see below

Principles of method if other than guideline:

Thirty male rats of Charles River CD strain, weighting 200 to 260 grams, were divided equally into 6 groups. Single, oral doses of the test material, suspended in corn oil, were administered to rats that were fasted overnight. Observations for mortality were recorded daily for 14 days.

GLP compliance:

not specified

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-[(2-hydroperoxybutan-2-yl)peroxy]butane-2-peroxol; butane-2,2-diperoxol

EC Number:

700-954-4

Cas Number:

1338-23-4

Molecular formula:

Mixture of C4H10O4 and C8H18O6

IUPAC Name:

2-[(2-hydroperoxybutan-2-yl)peroxy]butane-2-peroxol; butane-2,2-diperoxol

Test animals

Species:

rat

Strain:

other: Charles River CD

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200 to 260 g
- Fasting period before study: fasting overnight

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

corn oil

Doses:

508.1, 807.1, 1281, 2034, 3229, 5126 mg/kg bw

No. of animals per sex per dose:

5 male rats per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: body weight

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

1 017 mg/kg bw

Based on:

test mat.

95% CL:

>= 879 - <= 1 175

Mortality:

No mortality was shown up to doses level 807.1 mg/kg bw. All other animals were dead up to days 1. Details see in the field "Any other information on results incl. tables".

Any other information on results incl. tables

Dose levels (mg/kg bw)	Number of dead animals	Total moralities	hours	days
508.1	0/4
807.1	0/5
1281	0/5
2034	5/5
3229	5/5
5126	5/5

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The acute oral toxicity (LD50) value for methyl-ethylketone peroxide in DMP in male albino rats was calculated to be 1017 (879 - 1175) mg/kg.

Executive summary:

Methyl-ethylketone peroxide in DMP was tested in an acute oral toxicity study to thirty male rats of Charles River CD strain.

The thirty animals were divided equally into 6 groups. Single, oral doses of the test material, suspended in corn oil, were administered to rats that were fasted overnight. Observations for mortality were recorded daily for 14 days.

The acute oral toxicity (LD50) value for methyl-ethylketone peroxide in male albino rats was calculated to be 1017 (879 - 1175) mg/kg .