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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
Principles of method if other than guideline:
No deviations from Guideline.
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-amino-4,5-dichlorobenzene-1-sulfonic acid
EC Number:
700-413-2
Cas Number:
6331-96-0
Molecular formula:
C6 H5 Cl2 N O3 S
IUPAC Name:
2-amino-4,5-dichlorobenzene-1-sulfonic acid
Test material form:
other: solid
Details on test material:
Content of test item: 98.9% (not used for calculations)

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Remarks:
400
Doses:
2000 mg/kg
No. of animals per sex per dose:
6; three animals were used for each step.
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
discriminating dose
Effect level:
>= 2 000 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
other: cut-off LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Clinical Signs: No clinical signs were observed

Body Weights: There were no toxicologically significant effects on body weight or body weight gam.
Gross Pathology Findings: The necropsies performed at the end of the study revealed no particular findings

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

According to OECD guideline 423 the LD50 cut-off of Dichlororthanilsaure is > 5000 mg/kg bw. According to EU Directive 67 /548/EEC and EC Regulation 1272/2008 the test item is unclassified. So it is regarded as non-toxic after oral application.