Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-864-0 | CAS number: 75-35-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Warbrick et al. (2001) reported the outcome of a local lymph node assay. 1,1 -dichloroethene failed to induce an increase of the stimulation index above 3 at all tested concentrations . A stimulation index for 1,1 -dichloroethene of 0.91 was observed at the highest tested concentration of 50 %.
Therefore, according to this study, 1,1-dichloroethene is not a dermal sensitizer.
Migrated from Short description of key information:
1,1-dichloroethene, up to 50 % in acetone/olive oil, failed to induce an increase of the stimulation index in the Local Lymph Node Assay.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No information is available about respiratory sensitisation.
Migrated from Short description of key information:
No information is available about respiratory sensitisation.
Justification for classification or non-classification
Based on the negative results of a local lymph node assay, classification of 1,1 -dichloroethene as a sensitizer is not considered necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
