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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2005

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Topical application with occlusion, single dose for 4 hours.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Acrylonitrile
EC Number:
203-466-5
EC Name:
Acrylonitrile
Cas Number:
107-13-1
Molecular formula:
C3H3N
IUPAC Name:
prop-2-enenitrile

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
10 rats.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
topically applied acrylonitrile with occlusion.
Duration of exposure:
4 hours.
Doses:
200mg/kg.
No. of animals per sex per dose:
10 rats total, no further information available.
Control animals:
not specified
Details on study design:
No further information.
Statistics:
None reported.

Results and discussion

Preliminary study:
Not applicable/no information
Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Deaths 1/10 at 200 mg/kg bw
Mortality:
1 mortality occurred.
Clinical signs:
other: Slight oedema seen in 3 rats 24 hours following exposure.
Gross pathology:
No information.
Other findings:
No information.

Any other information on results incl. tables

No further information.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
1 rat died following 4 hours occluded topical application of acrylonitrile (200 mg/kg bw). Slight oedema was observed in 3 of the surviving rats 24 hours following exposure.
Executive summary:

1 rat (out of 10) died following 4 hours occluded topical application of acrylonitrile (200 mg/kg bw). Slight oedema was observed in 3 of the surviving rats 24 hours following exposure.