Registration Dossier
Registration Dossier
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EC number: 203-466-5 | CAS number: 107-13-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
An anonymous author (Japan MoE, 2011) reports a 96-hour LC50 of 5.1 mg/L (mean measured) for acrylonitrile in Oryzias latipes (gold medaka), a freshwater species. This study was performed on behalf of the Japanese Ministry of the Environment in accordance with a Japanese national method equivalent to OECD TG 203 and in compliance with GLP. The test was conducted under semi-static conditions with media renewal after 48 hours and with sealed test vessels to limit volatilisation losses of the test substance and maintain exposure concentrations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5.1 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 8.6 mg/L
Additional information
The Japan MoE (2011) study with O. latipes was reliably performed, with appropriate measures to ensure that exposure to acrylonitrile was satisfactorily maintained, and is considered to provide the key acute toxicity endpoint for freshwater fish. Knight & McHenery (AN Group, 1997) report a 96-hour LC50 of 8.6 mg/L for acrylonitrile in Sheepshead Minnow (Cyprinodon variegatus), a marine species. While numerous other results were summarised in the EU RAR, the Knight & McHenery study was considered the most reliable result in fish at the time the EU RAR was compiled, and this provides the acute toxicity endpoint for marine water fish. The 96-hour LC50 endpoints for O. latipes and C. variegatus are similar and there is no evidence to suggest a substantial difference in sensitivity to acrylonitrile between fresh- and sea-water fish.
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