Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
17 µg/L
Assessment factor:
10

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
17 µg/L
Assessment factor:
10
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
5 mg/L
Assessment factor:
10

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.019 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
no hazard identified

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.003 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

PNEC aquatic

Although the validity of the prolonged toxicity study in Daphnia by Tong et al (1996b) can be questioned in respect of reaching the conclusion that there are three valid long-term NOECs, the NOEC determined in the study is consistent with those established in the fish early life study and the algal toxicity study. A PNEC is derived using an assessment factor of 10. Applying this factor to the NOEC derived from the fish early life stage toxicity test in Pimephales promelas gives a PNEC of 17 μg/L.

PNEC STP

The results of microbial toxicity tests and biodegradation studies on acrylonitrile indicate a potential effect on microorganisms in wastewater treatment plants, at least on start-up. The reported EC50s range from 1- >1,800 mg/L. Results with acclimated microbial populations and in simulation tests have indicated no inhibitory effect of acrylonitrile at levels as high as 200 mg/L, and a conservative estimate of 50 mg/L for a NOEC in such populations has been assumed (EU RAR 2004). Application of a factor of 10 to this NOEC derives a PNEC of 5 mg/L for microorganisms in acclimated wastewater treatment plants handling acrylonitrile on a continuous basis. A factor of 10 is considered justified given the relatively large body of data on microbial toxicity of acrylonitrile.

PNEC sediment

No data are available; studies for this endpoint are waived on the basis of exposure. The PNEC sediment is of 0.0188 mg/kg is derived using the equilibrium partitioning method (EPM) based on the PNEC water of 0.017 µg/L.

PNEC soil

A PNEC for soil of 0.00268 mg/kg (based on PNEC (aquatic) of 17 μg/L) can be derived using the equilibrium partition approach.

Conclusion on classification

Acrylonitrile is listed in Annex VI of the CLP Regulation (EC) 1272/2008 with classification as H411, Aquatic Chronic Category 2.  No new data are available, therefore no change to this classification is proposed.