Registration Dossier
Registration Dossier
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EC number: 231-820-9 | CAS number: 7757-82-6
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 45
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 45
- Dose descriptor:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Occupational Exposure
Sodium sulphate can exist as dust (by-product) during manufacturing of various chemicals. Occupational exposure to sodium sulphate is possible by dermal contact and inhalation of the dust.
The occupational exposure limit value (OEL) is determined at 10 mg/m3 for an 8-hour exposure
Conclusion and classification:
Sodium sulfate is not toxic to the human. It is a naturally occurring substance which is reduced in the sulfur cycle.
Sodium sulfate does not need to be classified for human hazards.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 75
- Dose descriptor:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Consumer Exposure
Exposure to sodium sulfate occurs via drinking water and through naturally occurring amounts in foodstuffs. In drinking water (wells) concentrations up to 2 g/l were measured in the USA. The taste threshold for sodium sulfate is 250 – 900 mg/l. The maximum acceptable concentration for drinking water is 200 – 500 mg/l sulfate, and is based on taste (Ministry of Environment, Lands and Parks Province of British Columbia, Canada, 2000).
No data on the sulfate content of foodstuffs were found; however, according to WHO, sulfates are used as additives in the food industry and the estimated average daily intake of sulfate in food in the USA is 453 mg/person, based on data on food consumption and reported usage of sulfates as additives (WHO, 2003).An Acceptable Daily Intake for sodium sulfate has not been established.
Potential exposure to consumers also occurs from the use of detergents.
WHO/FAO did not set an ADI for sodium sulfate, since they consider this to be a substance of no concern. This was re-confirmed in the joint WHO/FAO meeting of June 2001.
Conclusion and classification:
Sodium sulfate is not toxic to the human. It is a naturally occurring substance which is reduced in the sulfur cycle.
Sodium sulfate does not need to be classified for human hazards.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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