Methyl methacrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given.

Data source

Reference

Reference Type:

publication

Title:

LC50 value for rats acutely exposed to methyl methacrylate monomer vapor.

Author:

Tansy MF, Landin WE, Kendall FM

Year:

1980

Bibliographic source:

J. Dent. Res. 59: 1074

Materials and methods

Principles of method if other than guideline:

Study to assess the acute inhalative toxicity of methyl methacrylate in rats after 4 h of exposure.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methyl methacrylate

EC Number:

201-297-1

EC Name:

Methyl methacrylate

Cas Number:

80-62-6

Molecular formula:

C5H8O2

IUPAC Name:

methyl 2-methylprop-2-enoate

Test material form:

liquid

Specific details on test material used for the study:

not specified in the publication

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Diet (e.g. ad libitum): Purina Laboratory Chow
- Water (e.g. ad libitum): tap water
- Acclimation period: at least one week

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

75 liter glass dynamic chambers were used. The generation of the test atmosphere was previously described by Tansy et al., Environ. Res., 11:66, 1976.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Concentrations:

0 (sham exposed), 4750, 6146, 8044, 10209, 13479 ppm (corresponding to ca. 19.5, 25.2, 33.0, 41.9 and 55.3 mg/L)

No. of animals per sex per dose:

10 (5 males, 5 females)

Control animals:

yes

Details on study design:

24 hour post-exposure observation period.

Statistics:

Interpolation of the linear regression of the log of the number of survivors against concentration of vapor. The LC50 was computed from responses of those groups where the mortality was greater than zero and less than 100%.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

29.8 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: corresponding to 7093 ppm

Remarks:

LC50 value coputed from responses of those groups where the mortality was greater than zero and less than 100 %

Mortality:

19.5 mg/L (4750 ppm): 8/10 animals died
25.2 mg/L (6146 ppm): 6/10 animals died
33.0 mg/L (8044 ppm): 2/10 animals died
41.9 mg/L (10209 ppm): 0/10 animals died
55.3 mg/L (13479 ppm): 0/10 animals died

Clinical signs:

other: not reported

Body weight:

not reported

Gross pathology:

not reported

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

Acute inhalation toxicity of methyl methacrylate was tested in Sprague Dawley rats with 4 hours whole body exposure. 5 dose groups of 10 animals each (5males, 5 females) were tested in cocentrations of 19.5 mg/l (4750 ppm) to 55.3 mg/l (13476 ppm).

LC50 acute: 29.8 mg/l ( 7093 ppm). (Result based on those dose groups where result was greater than zero and less than 100 % mortality.)