Registration Dossier
Registration Dossier
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EC number: 201-297-1 | CAS number: 80-62-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of simplex liquid methyl methacrylate monomer on cells
- Author:
- Welch A.B.
- Year:
- 1 978
- Bibliographic source:
- J. Biomed. Mat. Res. 12: 775-790 (1978)
Materials and methods
- Type of study / information:
- other: macrophage inhibition in vitro
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl methacrylate
- EC Number:
- 201-297-1
- EC Name:
- Methyl methacrylate
- Cas Number:
- 80-62-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- methyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Results and discussion
Any other information on results incl. tables
The ability of macrophages obtained from the peritoneal
cavity of mice to phagocyte Staphylococcus aureus was
inhibited by 0.5% MMA in the culture medium. Human
heparinised blood was incubated with concentrations of 0.5%,
1.25%, and 2.5% MMA for 15 min. The number of leucocytes
was reduced at a concentration of 2.5% MMA, no viable cells
were detected by the trypane blue method, at 1.25% the
number of viable leucocytes was reduced to about 50%.
Phagocytic polymorphonuclear neutrophils were damaged to a
greater extent than lymphocytes. Erythrocytes and platelets
were completely lysed at 2.5% MMA.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
