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EC number: 201-297-1 | CAS number: 80-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Occupational exposure of dental technicians to methyl methacrylate: Genotoxicity assessment
- Author:
- Soykut B, Erdem O, Yalcin CÖ, Üstündag A, Duydu Y, Akay C, Piskin B
- Year:
- 2 020
- Bibliographic source:
- Mutat Res Gen Tox En 852 (2020) 503159, 1-5
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
Test material
- Reference substance name:
- Methyl methacrylate
- EC Number:
- 201-297-1
- EC Name:
- Methyl methacrylate
- Cas Number:
- 80-62-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- methyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Method
- Ethical approval:
- confirmed, but no further information available
- Details on study design:
- For the genotoxicity tests, blood samples (5 ml) were collected in sodium heparin (BD Vacutainer, 367876, USA), lithium heparin (BD Vacutainer, 368884, USA), and EDTA- coated trace element (BD Vacutainer, 368381, USA) tubes via disposable intake sets (BD
Vacutainer, Eclipse 368609, USA). Preparations for the tests were initiated immediately after blood samples were taken.
Test groups:
Age (Mean±S.D.): 35.2±9.8
Duration of Work (Mean±S.D.): 16.1±9.1
Men: 61 (% 88.4)
Women: 8 (% 11.6)
Smoker: 40 (% 58)
Non-Smoker: 29 (% 42)
Control group:
Age (Mean±S.D.): 35.7±8.6
Duration of Work (Mean±S.D.): -
Men: 45 (% 67.2)
Women: 22 (% 32.8)
Smoker: 23 (% 34.3)
Non-Smoker: 44 (% 65.7) - Exposure assessment:
- measured
- Details on exposure:
- MMA levels in the ambient air of prosthesis laboratories were measured via sampling pump kit and Gastec Detector Tubes No.149 (Japan). Sampling was performed twice (before and after sample collection) in each of six different dental labs.
The detection limit was 1 ppm and the sampling volume was 200 ml.
The duration of each sampling was 4 min.
MMA levels in the ambient air of dental prosthesis laboratories were in the 25–50 ppm range, not exceeding international safety limits
Results and discussion
- Results:
- Comet tail intensity (%)
Test group: Mean = 4,8882
Control group: Mean= 4,75572
p:> 0.005
Applicant's summary and conclusion
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