Registration Dossier
Registration Dossier
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EC number: 231-753-5 | CAS number: 7720-78-7
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Crocidolite-induced lipid peroxidation in rat lung microsomes. I. Role of different ions.
- Author:
- Gulumian M, Kilroe-Smith TA
- Year:
- 1 987
- Bibliographic source:
- PMID 3034563 Environmental Research 43(1):267-73.
Materials and methods
- Endpoint addressed:
- basic toxicokinetics
Test material
- Reference substance name:
- Iron trichloride
- EC Number:
- 231-729-4
- EC Name:
- Iron trichloride
- Cas Number:
- 7705-08-0
- IUPAC Name:
- iron(3+) trichloride
Constituent 1
Results and discussion
- Details on results:
- Lipid peroxidation is increased by ferrous or ferric ions in rat lung microsomes both from rats pretreated with 3-methylcholanthrene and from untreated controls. This increase was dependent on the concentration of these ions in the reaction mixture. A reduced pH enhanced the rate of lipid peroxidation in line with increased solubility of iron salts at these pH values.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
