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EC number: 248-363-6 | CAS number: 27247-96-7
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- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
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- Short-term toxicity to fish
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Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 March 2010 to 21 April 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: compliant to GLP and testing guideline; adequate coherence between data, comments and conclusions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- yes
- Remarks:
- The reference item 4,4-DDT was expired since 31 October 2009
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Test temperature:
- The temperature during the analytical phase was around 22 °C.
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Autosampler, HPLC pump, Ultrasonic tank, Magnetic stirrer, Balance, Usual laboratory apparatus
- Column: Supelco - Length: 25 cm
- Particle size: 5.0 µm - Internal diameter: 4.6 mm
- Stationary phase: Supelcosil LC-CN
- Flow rate: 0.9 mL/min
- Injected volume: 40 µL - Wave length analysis: 210 nm
- Detection system: UV visible detector Hitachi L-4250
MOBILE PHASES
- Type: Methanol / water 45/55 v/v
- Solutes for dissolving test and reference substances: methanol
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column
Preparation of the thiourea solution
REFERENCE SUBSTANCES
- Identity: Acetanilide, methylbenzoate, isoproturon, 1,2,3-trichlorobenzene, pyrazophos and 4,4'-DDT
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 100 mg
- Quantity of acetanilide, 1,2,3-trichlorobenzene, pyrazophos or 4,4'-DDT introduced in the column: 10 mg
- Quantity of methylbenzoate introduced in the column: 20 mg
- Quantity of isoproturon introduced in the column: 5 mg
REPETITIONS
- Number of determinations: 2
EVALUATION
- The adsorption / desorption coefficient is given by the following equation: Logk' = a log Koc + b where k' is the capacity factor of the chromatographic column, a and b the coefficient of the calibration curve
The coefficients of the calibration curve are obtained through the chromatographic analysis of at least six analytical reference items with known adsorption coefficient. - Type:
- log Koc
- Value:
- 3.75
- Temp.:
- 22 °C
- Details on results (HPLC method):
- The results of the adsorption coefficient determination of 2-ETHYLHEXYL NITRATE are given in tables (see below).
First run: Using the Capacity factor and the adsorption coefficient of the reference items, the following calibration curve was obtained: log k' = 0.380 logKoc - 0.878
Second run: Using the Capacity factor and the adsorption coefficient of the reference items, the following calibration curve was obtained: log k' = 0.382 logKoc - 0.881
Variation in the retention times of the reference items are very small. Therefore a stable configuration of the HPLC column can be assumed. - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption / desorption coefficient of 2-ETHYLHEXYL NITRATE is equal to 3.75
Reference
First run:
Products | Mean Retention Time (min) | Value of the Capacity factor k' | Value of log k' | Value of log Koc |
Acetanilide | 4.68 | 0.28 | -0.55 | 1.25 |
Methyl benzoate | 5.80 | 0.59 | -0.23 | 1.80 |
Isoproturon | 6.73 | 0.84 | -0.074 | 1.86 |
1,2,3 -trichlorobenzene | 12.22 | 2.35 | 0.37 | 3.16 |
Pyrazophos | 20.15 | 4.52 | 0.66 | 3.65 |
4,4' DDT | 55.37 | 14.2 | 1.15 | 5.63 |
Test item | 16.45 | 3.51 | 0.54 | 3.74 |
Second run:
roducts | Mean Retention Time (min) | Value of the Capacity factor k' | Value of log k' | Value of log Koc |
Acetanilide | 4.67 | 0.28 | -0.55 | 1.25 |
Methyl benzoate | 5.80 | 0.59 | -0.23 | 1.80 |
Isoproturon | 6.74 | 0.85 | -0.072 | 1.86 |
1,2,3 -trichlorobenzene | 12.32 | 2.38 | 0.38 | 3.16 |
Pyrazophos | 20.41 | 4.59 | 0.66 | 3.65 |
4,4' DDT | 56.19 | 14.4 | 1.16 | 5.63 |
Test item | 16.63 | 3.56 | 0.55 | 3.75 |
Description of key information
Key value for chemical safety assessment
- Koc at 20 °C:
- 5 623
Additional information
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