Registration Dossier
Registration Dossier
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EC number: 204-673-3 | CAS number: 124-04-9
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case reports
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SIDS Initial Assessment Report for SIAM 18 for Adipic acid
- Author:
- OECD/SIDS
- Year:
- 2 004
- Bibliographic source:
- published by UNEP
- Report date:
- 2004
Materials and methods
- Type of sensitisation studied:
- respiratory
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- no guideline followed
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- adipic acid
- Reference substance name:
- Hexanedioic acid
- IUPAC Name:
- Hexanedioic acid
- Details on test material:
- Purity is 99.8%
Constituent 1
Constituent 2
Method
- Type of population:
- occupational
Results and discussion
- Results of examinations:
- Despite the wide use of adipic acid, only very few cases of skin or respiratory tract reactions are reported:
A positive patch test reaction to adipic acid (probably 1 % in alcoholic solution) was reported in a 51-year-old machine repairman with a 3- to 4-year history of work-related dermatitis of the hands and other exposed sites when working with powders in the synthesis of polyesters (Guin 2001).
Delayed cutaneous hypersensitivity to adipic acid was reported in a patch test (100 %) with a laboratory worker in a factory producing polyester resins. No further details are available in this case (Malten and Zielhuis 1964).
Two cases of bronchial asthma were reported in workers of a pharmaceutical factory coming into contact with spiramycin adipate powder. One of the workers developed an immediate asthmatic reaction also after inhalation of an aerosolized solution (10 mg/ml) of adipic acid. The reaction was reproducible and inhibited by previous administration of sodium cromoglycate. These findings suggested a hypersensitivity reaction to adipic acid by this patient (Moscato et al. 1984).
Applicant's summary and conclusion
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