Registration Dossier
Registration Dossier
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EC number: 204-126-9 | CAS number: 116-14-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
During studies in animals exposed whole body to TFE for up to 2 years, clinical observations did not show any signs of skin sensitisation.
Migrated from Short description of key information:
In accordance with section 2 of REACH Annex XI, the study on skin sensitisation need not be conducted as the substance is a gas.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
During studies in animals exposed whole body to TFE for up to 2 years, clinical observations did not show any signs of respiratory sensitisation.
Migrated from Short description of key information:
During studies in animals exposed whole body to TFE for up to 2 years, clinical observations did not show any signs of respiratory sensitisation.
Justification for classification or non-classification
The gaseous nature of TFE precludes the conductance of a skin sensitisation study in animals. Additionally, extensive inhalation studies on TFE by whole body exposure for up to 2 years showed no evidence of skin or respiratory sensitisation. Therefore, classification for skin and respiratory senstisation is not warranted under EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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