Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Data regarding the irritation potential of Ni sulfide are read-across from Ni subsulfide since results of a comprehensive bioaccessibility testing program evaluating release of Ni ion in synthetic sweat from various Ni compounds  indicate nickel sulphide and nickel subsulphide release similar amounts of nickel ion. Nickel subsulphide has been shown not to be a skin irritant in animal studies and is not classified as a skin irritant.  A comprehensive summary on this topic is provided in Section 7.4.1 of IUCLID and as Appendix B3 in the accompanying CSR.  

Key value for chemical safety assessment

Additional information

No studies that characterized the potential for NiS to cause irritation or corrosion were identified. Data from another sulfidic nickel compound are being read-across to Ni sulphide since results of a comprehensive bioaccessibility testing program evaluating release of Ni ion in synthetic sweat from various Ni compounds indicate nickel sulphide and nickel subsulphide release similar amounts of nickel ion. Nickel subsulphide has been shown not to be a skin irritant in animal studies and is not classified as a skin irritant. A comprehensive summary on this topic is provided inSection 7.4.1 of IUCLID and as Appendix B3 in the accompanying CSR. 

Information characterizing the potential for nickel subsulfide to cause irritation generally indicates that the compound is only slightly or mildly irritating. This indication is based on the results of two guideline-based, GLP studies recently conducted by Eurofins Product Safety Laboratory (EPSL, 2009a-b) evaluating eye and skin irritation potential. Collectively, these two studies provide reliable, adequate information to assess the irritant/corrosive properties of nickel subsulfide. The studies were specifically designed to evaluate the health hazard likely to arise from exposure by dermal or ocular application. Results demonstrated that nickel subsulfide can cause minor irritation in laboratory settings. However, all observed effects were fully reversible and generally classified as “slight” or “mild,” thus indicating a limited potential to be irritant/corrosive.

Justification for classification or non-classification

Ni sulfide is not classified for skin or eye irritation according to the 1st ATP to the CLP Regulation. No studies that characterized the potential for NiS to cause irritation or corrosion were identified. Data from another sulfidic nickel compound are being read-across to Ni sulphide since results of a comprehensive bioaccessibility testing program evaluating release of Ni ion in synthetic sweat from various Ni compounds indicate nickel sulphide and nickel subsulphide release similar amounts of nickel ion. Nickel subsulphide has been shown not to be a skin irritant in animal studies and is not classified as a skin irritant. A comprehensive summary on this topic is provided in Section 7.4.1 of IUCLID and as Appendix B3 in the accompanying CSR.