Nickel sulphide

GHS

General Information

Implementation:

EU

Remarks:

• Ni sulphide has not previously been classified for acute inhalation toxicity in the EU. However, a comprehensive read-across assessment was recently completed based on bioaccessibility data in synthetic lung fluids of various nickel compounds combined in vivo verification data for three source nickel substances. The bioaccessibility-based paradigm presented in a summary document in Section 7.2.2 and in an Appendix B2 to the CSR enables grouping of target Ni substances for classification purposes according to bioaccessibility in interstitial fluid as demonstrated. The outcome of this assessment indicates that Ni sulphide should be read-across from Ni subsulphide. Although Ni subsulphide is not currently classified for acute inhalation toxicity, a recently completed OECD-guideline compliant study reported an LC50=1.14 mg/L Ni subsulphide after 4 hours of exposure. This newly generated data demonstrate that Ni subsulphide should be classified as Acute Tox. 4: H332. This classification is reflected in the Nickel sulphide classification profile as Acute Tox. 4: H332.

Related composition

Related composition:

Nickel Sulphide

Nickel Sulphide - LE composition 1

Classification

Physical hazards

Explosives

Reason for no classification:

data conclusive but not sufficient for classification

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Reason for no classification:

data conclusive but not sufficient for classification

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data lacking

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - dermal

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - inhalation

Hazard category:

Acute Tox. 4

Hazard statement:

H332: Harmful if inhaled.

Skin corrosion / irritation

Reason for no classification:

data conclusive but not sufficient for classification

Serious eye damage / eye irritation

Reason for no classification:

data conclusive but not sufficient for classification

Respiratory sensitisation

Reason for no classification:

data conclusive but not sufficient for classification

Skin sensitisation

Hazard category:

Skin Sens. 1

Hazard statement:

H317: May cause an allergic skin reaction.

Aspiration hazard

Reason for no classification:

data lacking

Reproductive toxicity

Reason for no classification:

data conclusive but not sufficient for classification

Effects on or via lactation

Reason for no classification:

data conclusive but not sufficient for classification

Germ cell mutagenicity

Hazard category:

Muta. 2

Hazard statement:

H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Carcinogenicity

Hazard category:

Carc. 1A

Hazard statement:

H350: May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Route of exposure:

inhalation

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - repeated (STOT-RE)

Hazard category:

STOT Rep. Exp. 1

Hazard statement:

H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Affected organs:

lungs

Route of exposure:

inhalation

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Hazard category:

Aquatic Acute 1

Hazard statement:

H400: Very toxic to aquatic life.

Hazardous to the aquatic environment (long-term)

Hazard category:

Aquatic Chronic 1

Hazard statement:

H410: Very toxic to aquatic life with long lasting effects.

M-Factor acute:

1

M-Factor chronic:

1

Hazardous to the ozone layer

Reason for no classification:

data conclusive but not sufficient for classification

Labelling

Signal word:

Danger

Hazard pictogram

GHS08: health hazard

GHS07: exclamation mark

GHS09: environment

Hazard statements

H332: Harmful if inhaled.

H350: May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

H317: May cause an allergic skin reaction.

H410: Very toxic to aquatic life with long lasting effects.