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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1950
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Older published study

Data source

Reference
Reference Type:
publication
Title:
Toxicity of Sulfuric Acid Mist
Author:
Treon JF, Dutra FR, Cappel J, Sigmon H, & Younker W
Year:
1950
Bibliographic source:
American Medical Association (Reprinted from the Archives of Industrial Hygiene and Occupational Medicine, Vol. 2, December 1950, pages 716-734),

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Investigation of acute inhalation toxicity in different species, with different concentrations and durations of exposure
GLP compliance:
no
Remarks:
older published study
Test type:
other:
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphuric acid
EC Number:
231-639-5
EC Name:
Sulphuric acid
Cas Number:
7664-93-9
Molecular formula:
H2O4S
IUPAC Name:
sulfuric acid
Details on test material:
Sulphuric acid mists, 10-60%

Test animals

Species:
other: Rat, rabbit, guinea pig, mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
other: water
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
>= 2.75 - <= 7 h
Concentrations:
0.09 or 1.73 mg/l
No. of animals per sex per dose:
Various
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC100
Effect level:
0.087 mg/L air
Exp. duration:
2.75 h
Remarks on result:
other: Guinea pig
Sex:
not specified
Dose descriptor:
LC0
Effect level:
0.461 mg/L air
Exp. duration:
7 h
Remarks on result:
other: Rat
Sex:
not specified
Dose descriptor:
LC100
Effect level:
0.699 mg/L air
Exp. duration:
7 h
Remarks on result:
other: Rat
Sex:
not specified
Dose descriptor:
LC0
Effect level:
0.718 mg/L air
Exp. duration:
3.5 h
Remarks on result:
other: Rat
Sex:
not specified
Dose descriptor:
LC100
Effect level:
1.47 mg/L air
Exp. duration:
3.5 h
Remarks on result:
other: Rat
Sex:
not specified
Dose descriptor:
LC0
Effect level:
0.461 mg/L air
Exp. duration:
7 h
Remarks on result:
other: Mouse
Sex:
not specified
Dose descriptor:
other: LC40
Effect level:
0.699 mg/L air
Exp. duration:
7 h
Remarks on result:
other: Mouse
Sex:
not specified
Dose descriptor:
LC0
Effect level:
0.699 mg/L air
Exp. duration:
7 h
Remarks on result:
other: Rabbit
Sex:
not specified
Dose descriptor:
LC50
Effect level:
1.61 mg/L air
Exp. duration:
7 h
Remarks on result:
other: Rabbit
Sex:
not specified
Dose descriptor:
LC0
Effect level:
0.718 mg/L air
Exp. duration:
3.5 h
Remarks on result:
other: Rabbit, LC50 = 1.470 mg/l

Any other information on results incl. tables

Guinea-pigs, mice, rats, and rabbits were found to be less susceptible in that order. Observed lesions from the exposures included degenerative changes of the epithelium of the respiratory tract, pulmonary hyperemia and edema, focal pulmonary hemorrhages in some instances, and areas of atelectasis and emphysema in the lungs of all animals.

Applicant's summary and conclusion

Conclusions:
Guinea-pigs, mice, rats, and rabbits were found to be less susceptible in that order.
Executive summary:

Mortality data, length of survival, signs of intoxication, and pathological changes are reported for animals exposed to 0.090 or 1.73 milligrams per liter of air of sulfuric-acid mists in a test chamber. Guinea-pigs, mice, rats, and rabbits are found to be less susceptible in that order. Observed lesions from the exposures included degenerative changes of the epithelium of the respiratory tract, pulmonary hyperemia and edema, focal pulmonary hemorrhages in some instances, and areas of atelectasis and emphysema in the lungs of all animals.