Registration Dossier
Registration Dossier
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EC number: 203-631-1 | CAS number: 108-94-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-internal standards; estimation of the approximative LD50
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexanone
- EC Number:
- 203-631-1
- EC Name:
- Cyclohexanone
- Cas Number:
- 108-94-1
- Molecular formula:
- C6H10O
- IUPAC Name:
- cyclohexanone
- Details on test material:
- TS-Freetext:
Cyclohexanone
CAS No.: 108-94-1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous emulsion resp. solution in olive oil
- Details on oral exposure:
- no information
- Doses:
- Test substance given as a 2 - 50% aqueous emulsion with traganth resp. solution in olive oil.
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Test substance given as a 2 - 50% aqueous emulsion with traganth resp. solution in olive oil.
Observation period: 7 days - Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- approximate LD50
- Effect level:
- 1 890 mg/kg bw
- Remarks on result:
- other: test with 2 - 50% aqueous emulsion with traganth
- Dose descriptor:
- approximate LD50
- Effect level:
- 2 650 mg/kg bw
- Remarks on result:
- other: test with solution in olive oil
- Mortality:
- no data
- Clinical signs:
- other: Prone and lateral position, narcosis
- Gross pathology:
- Nothing abnormal detected.
Applicant's summary and conclusion
- Interpretation of results:
- other: harmful
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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