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EC number: 202-704-5 | CAS number: 98-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Abiotic degradation
Photodegradation in air: Cumene is reported to have reaction rates of 6.14 -7.8 10 -12 cm3 molec-1 s-1 and a DT50 of 1 -2.4 days by Lloyd et al. (1976).
Photodegradation in water: Cumene is reported to have a DT50 of 0.4-5.1 h by Mill et al. (1980).
No experimental data on photo-degradation and hydrolysis of cumene are presented in the EU-RAR (2001) and no more recent experimental data for these endpoints could be identified.
Hydrolysis of cumene is not expected to occur due to the lack of hydrolyzable functional groups.The test substance is regarded as readily biodegradable. Therefore, the performance of an experimental study on hydrolysis is unjustified. Cumene is expected to biodegrade in soil and may volatilize from the soil surface. Therefore, phototransformation in soil is expected to be of no or minor relevance for the fate of cumene in the terrestrial environment and the performance of an experimental study on photodegradation in soil is unjustified.
Biotic degradation
Two tests on biodegradation of cumene under aerobic and anaerobic conditions in water are available.
Under aerobic conditions a rapid degradation of cumene was detected following the guideline for BOD (biological oxygen demand) measurement over a period of 20 days. A degradation rate of > 60 % was determined within 10 days.The degradation potential under methanogenic conditions was examined with an anaerobic digesting sludge. Degradation was assessed in terms of net total gas (CH4plus CO2) produced, expressed as a percentageof the theoretical production (ThGP). Cumene proved not to be degraded. After an incubation period of 60 days at 35 °C 2 ± 2.8 % degradation was determined.
Cumene can be classified as readily biodegradable under aerobic conditions.
No explicit information about biodegradation of cumene in soil is available. Supporting information reveal that some types of soil bacteria are capable to degrade cumene. Therefore, determination of biodegradability in soil is not regarded necessary
The biodegradation of cumene was analysed in a water-sediment study. The first-order mineralization rate constant at the test concentration of 2.5 mg/L was calculated to be 0.02 d-1 (DT50 35 d).
Bioaccumulation
The bioconcentration factor BCF of cumene was calculated using BCFBAF (v 3.00). The calculation yielded a BCF of 94.69 L/kg wet wt taking into account the measured log Kow of 3.5. Based on the result, a low potential for bioconcentration is to be expected, which is confirmed by an experimental BCF of 35.5 found in a poorly documented bioconcentration study with fish (C. auratus). Moreover, a metabolism study in rat (see Toxicokinetics chapter) has shown that “no bioaccumulation potential was found based on study results”
In summary, there is no concern regarding the bioaccumulation of cumene in aquatic organisms.
Transport and distribution
Data on the sorption of cumene are given in the EU-RAR (2001) in section 3.1.2.1. A value of 884 L/kg is used for PEC-calculations which is also recommended for the current assessment.
Data on Henry's law constant of cumene is presented in the EU-RAR (2001) in section 1.3 (physico-chemical properties). It is reported that cumene has a Henry's law constant of 1010.80 Pa m³/mol. This value is also recommended for the current assessment.
Based on the recommended distribution constants air (99.7%) is the most important compartment for cumene.
The results for the other compartments were water (0.16%), soil (0.02%), and sediment (0.08%).
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