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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to terrestrial arthropods

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Endpoint:
toxicity to non-target arthropods on natural substrate (NTA other than pollinators)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See Attached Justification
Qualifier:
no guideline required
Principles of method if other than guideline:
- Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'
GLP compliance:
not specified
Specific details on test material used for the study:
HC Block Type Carbon Number Concentration (%w/w)
Mono-Aromatic (MoAr) 7 2.49
8 4.24
9 66.33
10 5.12
Naphthenic Mono-Aromatic (NMAr) 9 19.58
Total 97.76

The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity.
Analytical monitoring:
not required
Test organisms (species):
Folsomia candida
Animal group:
Collembola (soil-dwelling springtail)
Study type:
other: QSAR
Total exposure duration:
28 d
Reference substance (positive control):
no
Remarks:
Not required
Duration:
28 d
Dose descriptor:
other: LL50
Effect conc.:
90 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
mortality
Remarks on result:
other: QSAR prediction value
Duration:
28 d
Dose descriptor:
other: EL10
Effect conc.:
17.2 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
reproduction
Remarks on result:
other: QSAR prediction value
Validity criteria fulfilled:
yes
Conclusions:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for F. candida were 90 and 17.2 mg/lg dw respectively.
Executive summary:

The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) of the UVCB substance for F. candida were 90 and 17.2 mg/kg soil dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.

Endpoint:
toxicity to non-target arthropods on natural substrate (NTA other than pollinators)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See Attached Justification
Qualifier:
no guideline required
Principles of method if other than guideline:
- Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'
GLP compliance:
not specified
Specific details on test material used for the study:
HC Block Type Carbon Number Concentration (%w/w)
Mono-Aromatic (MoAr) 6 0.44
7 2.99
8 5.10
9 83.11
10 0.95
Naphthenic Mono-Aromatic (NMAr) 9 2.40
Di-Aromatic (DiAr) 10 1.13
n-Olefin 10 0.54
n-Paraffin (n-P) 10 0.14
11 0.33
Total 97.12

The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity.
Analytical monitoring:
not required
Test organisms (species):
Folsomia candida
Animal group:
Collembola (soil-dwelling springtail)
Study type:
other: QSAR
Total exposure duration:
28 d
Reference substance (positive control):
no
Remarks:
Not required
Duration:
28 d
Dose descriptor:
other: LL50
Effect conc.:
89.6 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
mortality
Remarks on result:
other: QSAR prediction value
Duration:
28 d
Dose descriptor:
other: EL10
Effect conc.:
17.2 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
reproduction
Remarks on result:
other: QSAR prediction value
Validity criteria fulfilled:
yes
Conclusions:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for F. candida were 89.6 and 17.2 mg/kg dw respectively.
Executive summary:

The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) of the UVCB substance for F. candida were 89.6 and 17.2 mg/kg soil dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.

Endpoint:
toxicity to non-target arthropods on natural substrate (NTA other than pollinators)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See Attached Justification
Qualifier:
no guideline required
Principles of method if other than guideline:
- Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'
GLP compliance:
not specified
Specific details on test material used for the study:
HC Block Type Carbon Number Concentration (%w/w)
Mono-Aromatic (MoAr) 7 1.55
8 31.91
9 17.86
10 2.89
12 2.29
13 0.67
Di-Aromatic (DiAr) 10 1.03
13 0.28
14 0.24
15 0.28
n-Olefin 5 0.27
10 21.06
11 0.41
i-Olefin 9 0.30
Total 81.03

The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity.
Analytical monitoring:
not required
Test organisms (species):
Folsomia candida
Animal group:
Collembola (soil-dwelling springtail)
Study type:
other: QSAR
Total exposure duration:
28 d
Reference substance (positive control):
no
Remarks:
Not required
Duration:
28 d
Dose descriptor:
other: LL50
Effect conc.:
103 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
mortality
Remarks on result:
other: QSAR prediction value
Duration:
28 d
Dose descriptor:
other: EL10
Effect conc.:
19.7 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
reproduction
Remarks on result:
other: QSAR prediction value
Validity criteria fulfilled:
yes
Conclusions:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for F. candida were 103 and 19.7 mg/kg dw respectively.
Executive summary:

The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) of the UVCB substance for F. candida were 103 and 19.7 mg/kg soil dw for short-term (LL50) and long-term effects (EL10), respectively.The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.

Endpoint:
toxicity to non-target arthropods on natural substrate (NTA other than pollinators)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See Attached Justification
Qualifier:
no guideline required
Principles of method if other than guideline:
- Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'
GLP compliance:
not specified
Specific details on test material used for the study:
HC Block Type Carbon Number Concentration (%w/w)
Mono-Aromatic (MoAr) 6 0.57
7 0.19
9 0.50
12 0.98
13 0.31
Di-Aromatic (DiAr) 10 0.27
n-Olefin 5 0.63
10 62.38
11 23.68
Total 89.52

The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity.
Analytical monitoring:
not required
Test organisms (species):
Folsomia candida
Animal group:
Collembola (soil-dwelling springtail)
Study type:
other: QSAR
Total exposure duration:
28 d
Reference substance (positive control):
no
Remarks:
Not required
Duration:
28 d
Dose descriptor:
other: LL50
Effect conc.:
290 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
mortality
Remarks on result:
other: QSAR prediction value
Duration:
28 d
Dose descriptor:
other: EL10
Effect conc.:
55.6 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
reproduction
Remarks on result:
other: QSAR prediction value
Validity criteria fulfilled:
yes
Conclusions:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for F. candida were 290 and 55.6 mg/kg dw respectively.
Executive summary:

The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) of the UVCB substance for F. candida were 290 and 55.6 mg/kg soil dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.

Endpoint:
toxicity to non-target arthropods on natural substrate (NTA other than pollinators)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See Attached Justification
Qualifier:
no guideline required
Principles of method if other than guideline:
- Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'
GLP compliance:
not specified
Specific details on test material used for the study:
HC Block Type Carbon Number Concentration (%w/w)
Mono-Aromatic (MoAr) 7 0.75
8 35.64
9 17.80
10 2.99
12 0.35
13 0.23
Di-Aromatic (DiAr) 10 0.22
n-Cyclohexane (n-CC6) 7 0.11
iso-Naphthenic (i-N) 8 0.10
n-Olefin 5 0.58
6 0.17
9 0.61
10 23.76
i-Olefin 6 0.21
n-Paraffin (n-P) 7 0.12
8 0.18
9 0.30
Total 84.13

The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity.
Analytical monitoring:
not required
Test organisms (species):
Folsomia candida
Animal group:
Collembola (soil-dwelling springtail)
Study type:
other: QSAR
Total exposure duration:
28 d
Reference substance (positive control):
no
Remarks:
Not required
Duration:
28 d
Dose descriptor:
other: LL50
Effect conc.:
103 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
mortality
Remarks on result:
other: QSAR prediction value
Duration:
28 d
Dose descriptor:
other: EL10
Effect conc.:
19.8 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
reproduction
Remarks on result:
other: QSAR prediction value
Validity criteria fulfilled:
yes
Conclusions:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for F. candida were 103 and 19.8 mg/kg dw respectively.
Executive summary:

The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) of the UVCB substance for F. candida were 103 and 19.8 mg/kg soil dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.

Endpoint:
toxicity to non-target arthropods on natural substrate (NTA other than pollinators)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See Attached Justification
Qualifier:
no guideline required
Principles of method if other than guideline:
- Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'
GLP compliance:
not specified
Specific details on test material used for the study:
HC Block Type Carbon Number Concentration (%w/w)
n-olefin 5 0.57
9 1.24
10 76.50
11 14.84
12 1.21
Total 94.37

The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity.

Analytical monitoring:
not required
Test organisms (species):
Folsomia candida
Animal group:
Collembola (soil-dwelling springtail)
Study type:
other: QSAR
Total exposure duration:
28 d
Reference substance (positive control):
no
Remarks:
Not required
Duration:
28 d
Dose descriptor:
other: LL50
Effect conc.:
285 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
mortality
Remarks on result:
other: QSAR prediction value
Duration:
28 d
Dose descriptor:
other: EL10
Effect conc.:
54.6 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
reproduction
Remarks on result:
other: QSAR prediction value
Validity criteria fulfilled:
yes
Conclusions:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for F. candida were 285 and 54.6 mg/kg dw respectively.
Executive summary:

The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) of the UVCB substance for F. candida were 285 and 54.6 mg/kg soil dw for short-term (LL50) and long-term effects (EL10), respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.

Endpoint:
toxicity to non-target arthropods on natural substrate (NTA other than pollinators)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See Attached Justification
Qualifier:
no guideline required
Principles of method if other than guideline:
- Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'
GLP compliance:
not specified
Specific details on test material used for the study:
HC Block Type Carbon Number Concentration (%w/w)
Mono-Aromatic (MoAr) 8 1.51
9 42.57
10 7.04
Naphthenic Mono-Aromatic (NMAr) 9 0.98
10 0.36
Di-Aromatic (DiAr) 10 8.24
11 0.85
n-Olefin 5 0.22
9 0.13
10 26.65
11 4.67
Total 93.21

The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity.
Analytical monitoring:
not required
Test organisms (species):
Folsomia candida
Animal group:
Collembola (soil-dwelling springtail)
Study type:
other: QSAR
Total exposure duration:
28 d
Reference substance (positive control):
no
Remarks:
Not required
Duration:
28 d
Dose descriptor:
other: LL50
Effect conc.:
111 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
mortality
Remarks on result:
other: QSAR prediction value
Duration:
28 d
Dose descriptor:
other: EL10
Effect conc.:
21.3 mg/kg soil dw
Nominal / measured:
estimated
Conc. based on:
other: QSAR prediction
Basis for effect:
reproduction
Remarks on result:
other: QSAR prediction value
Validity criteria fulfilled:
yes
Conclusions:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for F. candida were 111 and 21.3 mg/kg dw respectively.
Executive summary:

The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) of the UVCB substance for F. candida were 111 and 21.3 mg/kg soil dw for short-term (LL50) and long-term effects (EL10), respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.

Description of key information

The terrestrial toxicity was predicted by a QSAR, the PETROTOX v4.0 computer model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. The substances of this category fit within the criteria of the model and there are no reservations about the validity of the model runs. The predicted LL50 values for Folsomia candida ranged from 89.6 to 290 mg/kg soil dw. The predicted LL10 values for Folsomia candida ranged from 17.2 to 55.6 mg/kg soil dw.

Key value for chemical safety assessment

Additional information

The PETROTOX v4.0 model for sediment terrestrial organism calculates the constituent concentration in sediment or soil using the product composition (% mass) along with the total sediment/soil (s/s) loading rate (concentration of the full substance as added to the soil/sediment). The model then uses the equilibrium-partitioning calculations to convert aqueous-based effect concentrations (EC50, mmol/L) to soil or sediment based values (mmol/kg oc) for each constituent using the CTLBB for the soil or sediment organism. Then, it combines the s/s based concentration (mg/kg dw) and the effect concentrations in soil or sediment based values (mmol/kg oc) to compute toxic units for each constituent, which are then summed to determine the overall effect concentration (LC50ss) of the substance.
 
The predicted values were: 
Species Substance CAS No. LL50 / EL50 (mg/L) EL10 (mg/L)
Folsomia candida 68516-20-1 103 19.8
Folsomia candida 101316-62-5 90 17.2
Folsomia candida 68526-56-7 285 54.6
Folsomia candida 68477-54-3 103 19.7
Folsomia candida 94733-07-0 111 21.3
Folsomia candida 68478-10-4 290 55.6
Folsomia candida 65996-79-4 89.6 17.2