Registration Dossier
Registration Dossier
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EC number: 270-737-2 | CAS number: 68477-54-3 A complex combination of organic compounds obtained by the distillation of products from a steam cracking process. It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly in the range of C8 through C12.
Endpoint summary
Administrative data
Description of key information
Data on the acute aquatic toxicity of a number of streams are available for this category. The data from these streams have been read across to the other category members.
The studies were conducted to standard guidelines and according to GLP and so are considered fully reliable for use as key studies. The authors report the results based both on nominal loading rates (WAF) and mean measured concentrations. Short term toxicity to fish data gave a 96 hour LL50 range of 0.73 - 6.3 mg/L (WAF). Short term toxicity to aquatic invertebrates data gave a 48 hour EL50 range of 0.91-3.3 mg/L (WAF). Long term toxicity to aquatic invertebrates data gave a 6 -7 d EL10 for reproduction ranging from 0.49 to 0.85 mg/L. Toxicity to aquatic algae data gave a 72 hour ErL50 range of 1.3 -6.3 mg/L (WAF). The 56 day NOEC for the toxicity to activated sludge of a predominantly domestic sewage was 47.2 mg/L. The aquatic hazard assessment is currently on-going for Category L as part of the wider Environmental Testing Programme and a testing proposal for long-term toxicity to fish has been included in this dossier update.
In addition to the experimental data, the aquatic toxicity was predicted by a QSAR, the PETROTOX v4.0 computer model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry.The substances of this category fit within the criteria of the model and there are no reservations about the validity of the model runs. The predicted LL50/EL50 values for aquatic species ranged from 0.48 to >1000 mg/L. The predicted EL10 values for aquatic species ranged from 0.092 to 40.4 mg/L.
Additional information
QSAR predicted data:
The predicted 96-h LL50 (mortality) values for Oncorhynchus mykiss ranged from 0.65 to 4.07 mg/L.
The predicted 60-d EL10 ( hatch, survival, length and weight) values for Oncorhynchus mykiss ranged from 0.125 to 0.779 mg/L.
The predicted 48-h EL50 (mobility) values for Daphnia magna ranged from 1.29 to 7.10 mg/L.
The predicted 21-d EL10 (reproduction) values for Daphnia magna ranged from 0.218 to 1.27 mg/L.
The predicted 72-h EL50 (growth rate) values for Pseudokirchneriella subcapitata ranged from 0.48 to 2.99 mg/L.
The predicted 72-h EL10 (growth rate) values for Pseudokirchneriella subcapitata ranged from 0.092 to 0.574 mg/L.
The predicted 15-h EL50 (inhibition of total respiration) values for Activated Sludge ranged from 42 to >1000 mg/L.
The predicted 15-h EL10 (inhibition of total respiration) values for Activated Sludge ranged from 2.18 to 40.4 mg/L.
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