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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline study or GLP defined, no data on purity of test sample, no dose defined, no sex defined.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
Method: other: human n=7, saturated patch, right forearm, 24 h exposure, observation period: 7 days
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
EC Number:
701-257-8
IUPAC Name:
C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
Test material form:
liquid

Test animals

Species:
human
Strain:
not specified

Test system

Type of coverage:
other: ball of absorbent cotton and adhesive bandage
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
other: no control test persons described
Duration of treatment / exposure:
24 h
Observation period:
7 d
Number of animals:
7 test persons

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: 7 volunteers
Time point:
other: 8 h
Score:
ca. 0
Max. score:
8
Reversibility:
other: no effects observed
Remarks on result:
other: In a study in 7 humans the test substance (no dose defined) was applied to the right forearm and fixed with a ball of absorbent cotton and adhesive bandage for 24 hours. The observation:7d. No skin irritating or corrosive effects could be observed.

Any other information on results incl. tables

No skin irritating or corrosive effects observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

In a study in 7 humans (no sex defined) the test substance (no dose defined) was applied to the right forearm and fixed with a ball of absorbent cotton and adhesive bandage for 24 hours. The observation period was 7 days. No skin irritating or corrosive effects could be observed.