C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters

Endpoint summary

Description of key information

The acute oral toxicity of Mesamoll was tested in male Wistar rats treated via gavage with the doses: 5.0 and 15.0 ml/kg bw. The observation period was 14 days. No mortalities could be observed. Signs of intoxication were observed in the 15.0 ml/kg bw dose group (apathy, ruffled fur and diarrhea). The LD 50 was higher than 15 ml/kg bw (corresponds to 15.9 g/kg) (Löser E. / Kimmerle G., Bayer AG, 1975).
No acute inhalation study is available for Mesamoll.
In an acute dermal toxicological study Mesamoll was applied once to the shaved skin of the back of male and female Wistar rats. The observation time was 7 days and during this time period the test substance was not removed from the animals. No mortalities and no symptoms of toxicity could be observed. Therefore, regarding the density of Mesamoll (1.055 g/cm³ at 20 °C), the LD 50 was higher than 1055 mg/kg bw (Löser E. / Kimmerle G., Bayer AG, 1975).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No data on purity of test sample, non-GLP

Reason / purpose for cross-reference:

reference to same study

Principles of method if other than guideline:

Acute oral toxicity in male rats

GLP compliance:

not specified

Test type:

other: Acute oral toxicity in male rats

Limit test:

no

Species:

rat

Strain:

Wistar

Sex:

male

Route of administration:

oral: gavage

Vehicle:

other: none

Doses:

5.0; 15.0 ml/kg bw.

No. of animals per sex per dose:

10 male rats/dose

Control animals:

not specified

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

> 15 mL/kg bw

Dose (ml/kg bw)	Timepoint of death	Toxicological result (No.of mortalities/ Animals with Symptoms/ No.of animals)
5.0	-	0/0/10
15.0	-	0/10/10

Interpretation of results:

GHS criteria not met

Executive summary:

The acute oral toxicity of Mesamoll was tested in male Wistar rats treated via gavage with the doses: 5.0 and 15.0 ml/kg bw. The observation period was 14 days. No mortalities could be observed. Signs of intoxication were observed in the 15.0 ml/kg bw dose group (apathy, ruffled fur and diarrhea). The LD 50 was higher than 15 ml/kg bw (corresponds to 15.9 g/kg).

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

discriminating dose

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No OECD guideline or GLP defined; no data on purity of test sample.

Principles of method if other than guideline:

Acute percutan toxicity in male and female rats.

GLP compliance:

not specified

Test type:

other: acute percutan toxicity in male and female rats.

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

male/female

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Duration of exposure:

7 d

Doses:

1.0 ml/kg bw.

No. of animals per sex per dose:

5/sex/dose

Control animals:

not specified

Key result

Dose descriptor:

LD50

Effect level:

> 1 055 mg/kg bw

Dose (ml/kg bw)	sex	Timepoint of death	Toxicological result (No. of mortalities/ Animals with symptoms/ No.of animals)
1.0	male	-	0/0/5
1.0	female	-	0/0/5

Interpretation of results:

GHS criteria not met

Executive summary:

In this acute dermal toxicological study Mesamoll was applied once to the shaved skin of the back of male and female Wistar rats

(160 -180 g). The observation time was 7 days and during this timeperiod the test substance was not removed from the animals. No mortalities and no symptoms of toxicity could be observed. Therefore, regarding the density of Mesamoll ( 1.055 g/cm³ at 20 °C),

the LD 50 was higher than 1055 mg/kg bw.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

discriminating dose

Additional information

Conclusion: Overall Mesamoll shows no lethal effect after acute intake in the doses tested.

Justification for classification or non-classification

Classification is not required due to low acute toxicity.