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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
fish early-life stage toxicity
Type of information:
experimental study planned
Justification for type of information:
Testing proposal for Fish chronic study (OECD 210):
Testing proposal on vertebrate animals
Non-confidential name of substance:
- Pentaerythritol
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- No existing GLP long term fish toxicity study available.
- No existing non-GLP long term fish toxicity study available.
- Historical human data are not relevant in addressing this end-point
- No (Q)SAR result available
- Currently no in- vitro methods available to cover this endpoint.
- Weight of evidence: no sufficient data for WoE assessment
- Grouping and read-across: No information about structurally similar substance.

Indirect exposure of the aquatic compartment is likely. Therefore in accordance with REACH Regulation (EC) No. 1907/2006, Annex IX, sections 9.1.6 standard data requirements for any substance registered for 100 tonnes or more per year, long term toxicity testing is required to assess the aquatic toxicity. Furthermore, Pentaerythritol is registered for ANNEX X REACH registration. To comply with the standard REACH regulation, further data generation has been proposed for fish chronic toxicity endpoints in order to assess aquatic toxicity.
Further information on testing proposal in addition to information provided in the materials and methods section: n.a
Guideline:
OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)

Description of key information

Indirect exposure of the aquatic compartment is likely.  Therefore, in accordance with REACH Regulation (EC) No. 1907/2006, Annex IX, sections 9.1.5 standard data requirements for any substance registered for 100 tonnes or more per year, long term toxicity testing is required to assess the aquatic toxicity. Therefore, a new testing proposal on long term fish toxicity study (OECD 210) has been submitted.

Key value for chemical safety assessment

Additional information