Registration Dossier
Registration Dossier
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EC number: 200-539-3 | CAS number: 62-53-3
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: Reproduction
- Adequacy of study:
- other information
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Hardin, B.D. et al., Teratogen. Carcinogen. Mutagen. 7,|29-48 (1987)
- Title:
- No information
- Author:
- Piccirillo, V.J. et al., Screening of priority chemicals|for reproductive hazards (NTIS report no. PB83-257600).|Borriston Labs., Inc., Temple Hills (1983)
Materials and methods
Test material
- Reference substance name:
- Aniline
- EC Number:
- 200-539-3
- EC Name:
- Aniline
- Cas Number:
- 62-53-3
- Molecular formula:
- C6H7N
- IUPAC Name:
- aniline
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- Exposure period: 8 d
- Frequency of treatment:
- day 7 through day 14 of gestation
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 or 560 mg/kg bw
Basis:
- Control animals:
- yes
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
I. dams:
An increased mortality (6/50) and a significantly lower
than control mean weight change was noted, but no adverse
effects on reproductive outcome was observed.
II. fetuses:
A reduced birth weight, decreased weight gain and a reduced
offspring viability through the first 3 postpartum days was
noted.
Applicant's summary and conclusion
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